{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:08:43Z","timestamp":1773281323213,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Accurate prediction of extubation outcome could result in a significant reduction of respiratory morbidity in premature neonates. <b><i>Objectives:<\/i><\/b> To assess whether the respiratory muscle time constant of relaxation (<i>\u03c4<\/i>) predicted extubation outcome in mechanically ventilated, premature infants. <b><i>Methods:<\/i><\/b> Forty-six mechanically ventilated infants with a median gestational age of 26 (interquartile range [IQR] 25-29) weeks were prospectively studied. <i>\u03c4<\/i> was calculated from the reciprocal of the slope of the decline in airway pressure as a function of time. Measurements of <i>\u03c4<\/i> were done during 5-10 min of a spontaneous breathing test (SBT) prior to extubation. During the first and last minute of the SBT, <i>\u03c4<\/i><sub>1<\/sub> and <i>\u03c4<\/i><sub>2<\/sub>, respectively, were assessed, and the difference between them was calculated (&#x0394;<i>\u03c4<\/i>). <b><i>Results:<\/i><\/b> The median <i>\u03c4<\/i><sub>2<\/sub> was significantly higher in infants whose extubation failed (20.7 [IQR 12.9-34.7] s\/cm H<sub>2<\/sub>O) than in infants whose extubation succeeded (8.2 [IQR 6.2-17.8] s\/cm H<sub>2<\/sub>O, <i>p<\/i> = 0.002). The median &#x0394;<i>\u03c4<\/i> was significantly higher in infants whose extubation failed (10.3 [IQR 4.4-23.9] s\/cm H<sub>2<\/sub>O) than in infants whose extubation succeeded (-1.63 [IQR -5.7 to 0.3] s\/cm H<sub>2<\/sub>O, <i>p<\/i> = 0.001). Extubation failure was associated with <i>\u03c4<\/i><sub>2<\/sub> (<i>p<\/i> = 0.011) and &#x0394;<i>\u03c4<\/i> (<i>p<\/i> = 0.010) after correcting for postmenstrual age, patent ductus arteriosus, and intraventricular haemorrhage. Receiver operator characteristic curve analysis demonstrated that &#x0394;<i>\u03c4<\/i> predicted extubation failure with an area under the curve of 0.937. A &#x0394;<i>\u03c4<\/i> of +1.02 s\/cm H<sub>2<\/sub>O predicted extubation failure with 94% sensitivity and 83% specificity. <b><i>Conclusions:<\/i><\/b> The respiratory muscle time constant of relaxation during an SBT was significantly greater in infants whose extubation failed and could be used to predict extubation outcome in prematurely born infants.<\/jats:p>","DOI":"10.1159\/000477233","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T21:01:29Z","timestamp":1499979689000},"page":"251-257","source":"Crossref","is-referenced-by-count":21,"title":["Relaxation Rate of the Respiratory Muscles and Prediction of Extubation Outcome in Prematurely Born Infants"],"prefix":"10.1159","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-5301","authenticated-orcid":false,"given":"Theodore","family":"Dassios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ourania","family":"Kaltsogianni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5349","authenticated-orcid":false,"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118201"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.191015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181fe3431"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7210886"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/14767050410001668239"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950090103"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950090409"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/fetalneonatal-2011-301340"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/07420529909116856"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309264"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/fn.86.1.F32"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.166.4.518"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.081083"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300117"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.02.004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.6.1767"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.3.2004176"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200304-489CP"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(90)90025-E"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:35Z","timestamp":1745425655000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000477233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,10,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000477233","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}