{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:04:02Z","timestamp":1779163442867,"version":"3.51.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Backgrounds and Aims:<\/i><\/b> The serological risk-prediction system combined the pepsinogen (PG) test, and anti-<i>Helicobacter pylori<\/i> antibody is available for evaluation of gastric cancer risk. In this system, chronic atrophic gastritis (CAG) or <i>H. pylori<\/i> infection is diagnosed. Subjects with <i>H. pylori<\/i> negative and PG test negative (group A) are supposed to be those who have never been infected with <i>H. pylori<\/i> and are at extremely low risk for gastric cancer. However, a certain proportion of patients with CAG has been identified as the extremely low-risk group (group A). Here we examined endoscopic atrophy and investigated its relationship with the ABC classification system. <b><i>Methods:<\/i><\/b> We examined 540 patients. All patients underwent an endoscopic examination for evaluating corpus atrophy. Fasting sera were collected and serum PGs and anti-<i>H. pylori <\/i>antibody (Hp-Ab) titer (E-plate Eiken) were evaluated. <b><i>Results:<\/i><\/b> Of the 540 patients, 306 were classified into group A. However, 136 of them showed signs of endoscopic atrophy (group A with CAG). Group A with CAG frequently comprised the elderly. A new titer cut-off (<3 U\/mL) of the Hp-Ab improved the discrimination of group A with CAG by 8%. <b><i>Conclusion:<\/i><\/b> The prevalence of group A with CAG patients is a critical problem, especially in elderly subjects.<\/jats:p>","DOI":"10.1159\/000477239","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T21:01:51Z","timestamp":1496350911000},"page":"314-318","source":"Crossref","is-referenced-by-count":26,"title":["Serological Evaluation of Gastric Cancer Risk Based on Pepsinogen and <b><i>Helicobacter pylori <\/i><\/b>Antibody: Relationship to Endoscopic Findings"],"prefix":"10.1159","volume":"95","author":[{"given":"Takahiro","family":"Kotachi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Boda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Kiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiji","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0897-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.87.405"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109783"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-006-0397-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00889.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12101"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-015-0469-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12987"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s005350300060"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1098086"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1999.09016.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27965"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/den.12031"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477239","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:38Z","timestamp":1745425658000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000477239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,7,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000477239","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}