{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:33:05Z","timestamp":1760189585785,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> The genetic basis of sepsis susceptibility in preterm infants remains understudied. Herein, we investigated the nucleotide binding-oligomerization domain (NOD)-like receptor (NLR) family of immune receptors as putative loci for preterm sepsis susceptibility. <b><i>Objective:<\/i><\/b> To determine whether single nucleotide polymorphisms (SNPs) in NLR genes are associated with blood stream infections (BSI) in premature infants. <b><i>Methods:<\/i><\/b> An international cohort of infants with gestational age (GA) <35 weeks were genotyped for SNPs in the <i>ATG16L1<\/i>, <i>CARD8<\/i>, <i>NLRP3<\/i>, <i>NOD2<\/i>, and <i>NOD1 <\/i>genes. &#x03C7;<sup>2<\/sup> and logistic regression analyses were used to examine relationships between NLR variants and BSI. <b><i>Results:<\/i><\/b> Among 764 infants, 138 developed BSI, 113 had gram-positive bacterial (GPB) BSI, and 28 had gram-negative bacterial (GNB) BSI. Infants with BSI had a lower birth weight and GA (<i>p<\/i> < 0.001), but did not differ in gender, race, or chorioamnionitis. <i>NLR<\/i> variants were not associated with GPB or GNB BSI in the entire cohort. The CC genotype of the NOD1 SNP <i>(<\/i>rs6958571) was associated with increased GPB BSI in extremely low birth weight (ELBW, birth weight <1,000 g) infants (OR = 3.3, 95% CI: 1.4-7.5, <i>p<\/i> = 0.003, <i>n<\/i> = 362) and in Caucasian infants (OR = 2.5, 95% CI: 1.2-5.4, <i>p<\/i> = 0.016, <i>n<\/i> = 535). Regression models adjusting for clinical variables identified ELBW status and the <i>NOD1<\/i> CC genotype as risk factors for GPB BSI in Caucasian infants. <b><i>Conclusions:<\/i><\/b> In this study investigating relationships between <i>NLR<\/i> variants and sepsis in infants with GA <35 weeks, the <i>NOD1 (<\/i>rs6958571) SNP was associated with GPB BSI in Caucasian infants and ELBW infants. Replication of our results in an independent cohort would support a role for NLR variants in determining sepsis risk in ELBW infants.<\/jats:p>","DOI":"10.1159\/000477433","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T21:01:54Z","timestamp":1501707714000},"page":"354-358","source":"Crossref","is-referenced-by-count":5,"title":["A Potential Role for the <b><i>NOD1<\/i><\/b> Variant <b><i>(<\/i><\/b>rs6958571) in Gram-Positive Blood Stream Infection in ELBW Infants"],"prefix":"10.1159","volume":"112","author":[{"given":"Venkatesh","family":"Sampath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Mulrooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aloka L.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery","family":"Garland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal M.","family":"Lavoie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dagle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pippa","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(12)70019-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(03)00046-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nri2075"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.80"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000112100.61253.85"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000658"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092239"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01146.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12559"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.260"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.07.060"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050854"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000192246.47959.b2"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes404"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:30:02Z","timestamp":1745425802000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000477433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000477433","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5267791","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2017]]}}}