{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:25:00Z","timestamp":1790277900415,"version":"4.1.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Different epidemiological studies, especially in Europe, have estimated the incidence density of myasthenia gravis (MG) to range between 1.7 and 21.3\/1,000,000\/person-year; however, data from regions such as Latin America are scarce. This study is aimed at estimating the incidence and prevalence of acquired MG in Buenos Aires, Argentina. <b><i>Methods:<\/i><\/b> The study population comprised of affiliates of the Italian Hospital Medical Care Program, a prepaid health maintenance organization located in Buenos Aires. The evaluation method for case detection included a retrospective search from January 1, 2006, through December 31, 2012. <b><i>Results:<\/i><\/b> Of the 60 cases identified, 36 (60%) were females. The median age at diagnosis was 69 years (IQR 51.5-79). The mean age at diagnosis was 63.3 years (SD \u00b120). A total of 28 patients (46.7%) had generalized MG and 32 had ocular MG (53.3%). Thirty five patients (58.3%) had acetylcholine receptor antibodies and 2 (3.3%) had muscle-specific receptor tyrosine kinase antibodies. The crude incidence density (ID) of MG was 61.33 per 1,000,000 person-years (95% CI 47.62-79.99). The adjusted ID for the Argentinean population was 38.8 per 1,000,000 person-years (95% CI 27.09-50.51) and for the Buenos Aires population was 47.49 (95% CI 34.73-60.25). <b><i>Conclusions:<\/i><\/b> The results obtained are similar to those published for other geographical areas.<\/jats:p>","DOI":"10.1159\/000477733","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T21:04:16Z","timestamp":1498165456000},"page":"119-123","source":"Crossref","is-referenced-by-count":21,"title":["Incidence of Autoimmune Myasthenia Gravis in a Health Maintenance Organization in Buenos Aires, Argentina"],"prefix":"10.1159","volume":"48","author":[{"given":"Mariela","family":"Bettini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Cristiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina","family":"Pagotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Giunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Rugiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/85520"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22312"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176067.32186.a3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.1.255"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5651-z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3233\/978-1-60750-588-4-1045"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000050461.05432.C5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23964"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1254.055"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03698.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03089.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318217e735"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-46"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2015.10.009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000311012"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000080093"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24348"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:33:02Z","timestamp":1745425982000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000477733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":18,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2017,8,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000477733","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}