{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:00Z","timestamp":1787017920316,"version":"build-2736575974"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>A 55-year-old man, nonsmoker, with a HIV-positive history came to our attention in February 2017. He was on treatment with Stribild&lt;sup&gt;TM&lt;\/sup&gt;, 1 capsule daily (150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine, and 245 mg tenofovir disoproxil). The CD4+\/CD8+ cellular count was 326\/\u00b5L (normal values: 404\u20131,612); the CD3+\/CD8+ cellular count was 819\/\u00b5L (normal values: 220\u20131,219). The CD4\/CD8 ratio was 0.40 (normal value: &amp;#x3e;1). Several typical genital wart lesions were present at the penis shaft and at the level of the neck and the corona of glans. These lesions were present for 2 years. Several cryotherapy sessions (a total of 10 procedures) had been performed with partial success. At the initial visit a total of 5 lesions were present. Treatment with topical Polyphenon E 10% 3 times a day was prescribed and started. After 1 month of treatment the lesions were reduced to 2. Treatment was very well tolerated. After 8 weeks of treatment no more lesions were observed and therefore a complete clearance was obtained. Local tolerability was evaluated to be very good by the patient.<\/jats:p>","DOI":"10.1159\/000477839","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T17:01:20Z","timestamp":1498582880000},"page":"55-59","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Tolerability of Polyphenon E in \u201cDifficult-to-Treat\u201d Multiple Genital Warts in an HIV-Positive Male Subject"],"prefix":"10.1159","volume":"9","author":[{"given":"Mauro","family":"Grandolfo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7559-1202","authenticated-orcid":false,"given":"Massimo","family":"Milani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00179-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80315-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131304"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nrc700"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.2.560"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04066.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09375.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08520.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204672200"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1021\/tx990003t"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181719b60"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03796.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2012.676036"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000245960.52668.e5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00107-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1086\/381681"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.04.012"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-009-1917-3"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.10.6764"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477839","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:33:37Z","timestamp":1745411617000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000477839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,27]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,12,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000477839","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,27]]}}}