{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:58:50Z","timestamp":1780484330289,"version":"3.54.1"},"reference-count":32,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Recently, sustained inflations (SI) during chest compression (CC) (CC+SI) have been suggested as an alternative to the current approach during neonatal resuscitation. No previous study compared CC+SI using CC rates of 90\/min to the current 3:1 compression:ventilation ratio (C:V). <b><i>Objective:<\/i><\/b> To determine whether CC+SI versus a 3:1 C:V reduces the time to the return of spontaneous circulation (ROSC) and improves hemodynamic recovery in newborn piglets with asphyxia-induced bradycardia. <b><i>Intervention and Measurements:<\/i><\/b> Term newborn piglets were anesthetized, intubated, instrumented, and exposed to 45-min normocapnic hypoxia followed by asphyxia. Cardiopulmonary resuscitation (CPR) was initiated when the heart rate decreased to 25% of baseline. Piglets were randomized into 3 groups: CC during SI at a rate of 90 CC\/min (SI+CC 90, <i>n<\/i> = 8), a 3:1 C:V using 90 CC and 30 inflations (3:1, <i>n<\/i> = 8), or a sham group (<i>n<\/i> = 6). Cardiac function, carotid blood flow, cerebral oxygenation, and respiratory parameters were continuously recorded throughout the experiment. <b><i>Results:<\/i><\/b> CC+SI significantly reduced the median (IQR) time of ROSC, i.e., 34 s (28-156 s) versus 210 s (72-300 s) in the 3:1 group (<i>p<\/i> = 0.048). CC+SI also significantly reduced the requirement for 100% oxygen, improved respiratory parameters, and resulted in a similar hemodynamic recovery. <b><i>Conclusions:<\/i><\/b> CC+SI during CPR significantly improved ROSC in a porcine model of neonatal resuscitation. This is of considerable clinical relevance because improved respiratory and hemodynamic parameters potentially minimize morbidity and mortality in newborn infants.<\/jats:p>","DOI":"10.1159\/000477998","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T21:01:54Z","timestamp":1501707714000},"page":"337-346","source":"Crossref","is-referenced-by-count":43,"title":["Chest Compressions during Sustained Inflations Improve Recovery When Compared to a 3:1 Compression:Ventilation Ratio during Cardiopulmonary Resuscitation in a Neonatal Porcine Model of Asphyxia"],"prefix":"10.1159","volume":"112","author":[{"given":"Elliott S.","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immanuel","family":"G\u00f6rens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-1523","authenticated-orcid":false,"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Fun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3373D"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.08.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2012.09.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.3.618"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2009.71"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.4.e40"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.025"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.10.877"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002289"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.07.014"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.08.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000412"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.04.012"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(81)90320-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31821d06a1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157249"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1061498"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.165"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2016.06.014"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181b3b110"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000143397"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146574"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00162.2013"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.059303"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308363"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1159\/000357609"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3182125f7f"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.06.007"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.200386"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1159\/000439020"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1159\/000447663"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971119"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/477998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:34:54Z","timestamp":1745426094000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000477998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000477998","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5267782","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}