{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:07Z","timestamp":1745468887496,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Although growth hormone deficiency (GHD) is an important issue in pediatric patients, adult GHD (AGHD) is a neglected field of endocrinology in China. The aim of this study is to characterize the clinical, hormonal, and radiological features in childhood-onset AGHD (CO AGHD) in a single center in China and to compare them with counterparts from Japan. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The medical records of 78 Chinese patients with CO AGHD were reviewed and compared with data from the HypoCCS database study from Japan (&lt;i&gt;N&lt;\/i&gt; = 69). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The majority of our patients had pituitary stalk interruption, while hypothalamo-pituitary tumors were the most common cause of CO AGHD in Japan. Chinese patients had a lag of 6 years for diagnosis. The majority of both groups had multiple pituitary hormone deficiencies. Body mass index and lipid profiles were similar between the 2 patient groups. Dyslipidemia and hyperuricemia were the most common metabolic disturbances in Chinese patients. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our findings confirm that there are possible regional differences in the etiology, metabolic characteristics, and hormonal status in CO AGHD patients in different countries in Asia.<\/jats:p>","DOI":"10.1159\/000478527","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T21:01:19Z","timestamp":1500411679000},"page":"155-159","source":"Crossref","is-referenced-by-count":6,"title":["Childhood-Onset Adult Growth Hormone Deficiency: Clinical, Hormonal, and Radiological Assessment in a Single Center in China"],"prefix":"10.1159","volume":"88","author":[{"given":"Hongbo","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kemin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0179"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1390460"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030346"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0523"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13291"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0273"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-363"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1001-9294(16)30046-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0179"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1005-1201.2010.06.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030134"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510343"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13633-016-0024-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-014-0610-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.76.4.8473387"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/478527","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/478527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:37:35Z","timestamp":1745426255000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000478527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,9,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000478527","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2017]]}}}