{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:15:54Z","timestamp":1790363754811,"version":"4.1.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Abnormal interhemispheric synchrony has been described in many clinical compromises in brain function, but its prognostic value in neonatal hypoxic-ischemic encephalopathy (HIE) is unknown. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The study aimed at describing the frequency of abnormal interhemispheric synchrony in infants with HIE and to explore its prognostic value. The main outcome was survival without major disabilities. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We performed a single-center retrospective cohort study and enrolled 40 neonates with HIE who underwent hypothermia. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Abnormal interhemispheric synchrony was observed in 23% of the patients with HIE. Sensitivity and specificity values for predicting survival without major disabilities were 90 and 67% for seizures, 50 and 97% for status epilepticus, 60 and 97% for highly abnormal EEG in the first 48 h, and 80 and 97% for EEG asynchrony, respectively. The prognostic value of asynchrony improved to 100% sensitivity, whereas specificity remained unchanged, when associated with highly abnormal EEG within the first 48 h of life. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Abnormal interhemispheric synchrony was observed in a quarter of the patients with HIE. This pilot study suggests that the prognostic value of asynchrony is excellent, especially when combined with EEG background analysis.<\/jats:p>","DOI":"10.1159\/000478964","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T21:01:44Z","timestamp":1502398904000},"page":"359-364","source":"Crossref","is-referenced-by-count":9,"title":["Abnormal Interhemispheric Synchrony in Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Pilot Study"],"prefix":"10.1159","volume":"112","author":[{"given":"Elise","family":"Leroy-Terquem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Isabelle","family":"Vermersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Assaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Boddaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lapillonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Magny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71048-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2011.03.032"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.017"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(95)00171-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(90)90208-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2190"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/ejpn.2001.0496"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2012.09.091"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00517-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0370-4475(77)80027-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3182872ac2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(82)90106-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.014"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.3.461"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1297"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90063-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(79)90147-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1018167"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.01030"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/478964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/478964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:48Z","timestamp":1745426448000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000478964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000478964","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}