{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:37:44Z","timestamp":1791959864521,"version":"4.3.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are nowadays recognized as spectrum disorders with a molecular link, the TAR DNA-binding protein 43 (TDP-43), rendering it a surrogate biomarker for these disorders. <b><i>Methods:<\/i><\/b> We measured cerebrospinal fluid (CSF) levels of TDP-43, beta-amyloid peptide with 42 amino acids (A\u03b2<sub>42<\/sub>), total tau protein (\u03c4<sub>T<\/sub>), and tau protein phosphorylated at threonine 181 (\u03c4<sub>P-181<\/sub>) in 32 patients with ALS, 51 patients with FTD, and 17 healthy controls. Double-sandwich commercial enzyme-linked immunosorbent assays were used for measurements. <b><i>Results:<\/i><\/b> Both ALS and FTD patients presented with higher TDP-43 and \u03c4<sub>T<\/sub> levels compared to the control group. The combination of biomarkers in the form of the TDP-43 \u00d7 \u03c4<sub>T<\/sub> \/ \u03c4<sub>P-181<\/sub> formula achieved the best discrimination between ALS or FTD and controls, with sensitivities and specificities >0.8. <b><i>Conclusion:<\/i><\/b> Combined analysis of TDP-43, \u03c4<sub>T<\/sub>, and \u03c4<sub>P-181<\/sub> in CSF may be useful for the antemortem diagnosis of ALS and FTD.<\/jats:p>","DOI":"10.1159\/000478979","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T08:51:41Z","timestamp":1503478301000},"page":"144-152","source":"Crossref","is-referenced-by-count":56,"title":["Cerebrospinal Fluid TAR DNA-Binding Protein 43 Combined with Tau Proteins as a Candidate Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Spectrum Disorders"],"prefix":"10.1159","volume":"44","author":[{"given":"Mara","family":"Bourbouli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rentzos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-8711","authenticated-orcid":false,"given":"Anastasia","family":"Bougea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Zouvelou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios 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