{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:48:58Z","timestamp":1762004938347,"version":"3.40.5"},"reference-count":29,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Objectives:<\/i><\/b> Predictive models for heart failure (HF) in heterogeneous populations have had limited success. We examined cardiac computed tomography angiography (CTA) predictors of HF or cardiovascular death (HF-CVD) in a prospective study of asymptomatic diabetics undergoing baseline assessment by CTA. <b><i>Methods:<\/i><\/b> The subjects (<i>n<\/i> = 735, aged 55-74 years, 51.2% women) had no clinical history of cardiovascular disease at study entry. Coronary artery calcium (CAC) score, CTA-defined coronary atherosclerosis, cardiac chamber volumes, and clinical data were collected and late outcome events recorded over 8.4 \u00b1 0.6 years (range 7.3-9.3). <b><i>Results:<\/i><\/b> HF-CVD occurred in 41 (5.6%) subjects, with HF occurring mostly (19\/23, 82.6%) in subjects without preceding myocardial infarction. Baseline univariate clinical outcome predictors of HF-CVD included older age (<i>p<\/i> = 0.027), the duration of diabetes (<i>p<\/i> = 0.004), HbA1c (<i>p<\/i> < 0.0001), microvascular disease (retinopathy, microalbuminuria) (<i>p<\/i> < 0.0001), and systolic blood pressure (<i>p<\/i> = 0.035). Baseline univariate CTA predictors included CAC score (<i>p<\/i> = 0.004), coronary stenosis (<i>p<\/i> = 0.047), and a CTA-defined left\/right atrial (LA\/RA) volume ratio >1 (<i>p<\/i> < 0.0001). Independent predictors were an LA\/RA volume ratio >1, microvascular disease, and systolic blood pressure (model C-statistic 0.792, 95% CI 0.758-0.824). Measures of the extent of coronary artery disease (CAD) were not independent predictors of HF-CVD. <b><i>Conclusions:<\/i><\/b> In a low- to moderate-risk asymptomatic diabetic population, CTA LA enlargement (LA\/RA volume ratio) but not the extent of CAD had independent prognostic value for HF-CVD in addition to the clinical variables.<\/jats:p>","DOI":"10.1159\/000478995","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T21:01:33Z","timestamp":1503003693000},"page":"218-227","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac Computed Tomography Angiographic Findings as Predictors of Late Heart Failure in an Asymptomatic Diabetic Cohort: An 8-Year Prospective Follow-Up Study"],"prefix":"10.1159","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1865-7919","authenticated-orcid":false,"given":"David A.","family":"Halon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jubran","family":"Ayman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronen","family":"Rubinshtein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barak","family":"Zafrir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mali","family":"Azencot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil S.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014796"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.061"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.04.019"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022194"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.427"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvv035"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.633"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5036"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003226"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80105-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0286"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.08.080"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.1622"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.04.006"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.03.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.151043"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.054"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev027"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.08.004"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2668"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv134"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-015-0263-7"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.05.006"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00291-0"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2681-3"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69201-5"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw022"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/478995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/478995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:41:24Z","timestamp":1745426484000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000478995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,12,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000478995","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2017]]}}}