{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:28:37Z","timestamp":1791646117611,"version":"4.3.4"},"reference-count":38,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> Probiotics appear to improve <i>Helicobacter pylori<\/i>-associated dyspepsia via an inhibitory effect on <i>H. pylori;<\/i> however, uncertainty exists regarding their effects in <i>H. pylori<\/i>-uninfected individuals. We evaluated the efficacy of <i>Lactobacillus gasseri<\/i> OLL2716 (<i>L. gasseri<\/i> OLL2716) on <i>H. pylori<\/i>-uninfected individuals with functional dyspepsia (FD). <b><i>Methods:<\/i><\/b> A double-blind, parallel-group, placebo-controlled, randomized, controlled trial was performed. Participants were randomly assigned to ingest <i>L. gasseri<\/i> OLL2716-containing yogurt (<i>L. gasseri<\/i> OLL2716 group) or <i>L. gasseri<\/i> OLL2716-free yogurt (placebo group) for 12 weeks. Participants completed questionnaires that dealt with a global assessment as well as symptom severity. The per-protocol (PP) population was evaluated for efficacy in accordance with a plan prepared beforehand. <b><i>Results:<\/i><\/b> Randomization was performed on 116 individuals; the PP population consisted of 106 individuals (mean age 42.8 \u00b1 9.0). The impressions regarding the overall effect on gastric symptoms were more positive in the <i>L. gasseri<\/i> OLL2716 group compared to that in the placebo group (statistical trend; <i>p<\/i> = 0.073). The elimination rate for major FD symptoms was 17.3 and 35.3% in the placebo and <i>L. gasseri<\/i> OLL2716 groups respectively (<i>p<\/i> = 0.048). <b><i>Conclusion:<\/i><\/b><i>L. gasseri<\/i> OLL2716 has beneficial effects on FD without <i>H. pylori<\/i> involvement.<\/jats:p>","DOI":"10.1159\/000479000","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T21:01:53Z","timestamp":1501707713000},"page":"92-102","source":"Crossref","is-referenced-by-count":76,"title":["The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study"],"prefix":"10.1159","volume":"96","author":[{"given":"Toshihiro","family":"Ohtsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisakuni","family":"Sekino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,7,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.059"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04640.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199805000-00007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.027"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.158"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.04.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.167270"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1017-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.10.025"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01427.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303857"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002096"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7490452"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2014-9158"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.12938\/bmfh.2014-017"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000452361"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06949.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12987"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301454"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12348"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02774.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12444"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.010"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12370"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.003"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02950-05"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.5264\/eiyogakuzashi.71.171"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(03)00053-4"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01449.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000452359"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.2.150"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.028"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12419"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FPJ04027X"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.574730"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2016-000109"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:41:29Z","timestamp":1745426489000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000479000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,9,12]]}},"URL":"https:\/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