{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:22:12Z","timestamp":1780345332243,"version":"3.54.1"},"reference-count":37,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Optic nerve hypoplasia (ONH), a leading cause of pediatric blindness, is associated with brain malformations and hypopituitarism in the constellation known as septo-optic dysplasia. Neuroimaging is used to anticipate hypopituitarism, but with unconfirmed reliability. We report prospective findings on the association of hypopituitarism with brain malformations. <b><i>Methods:<\/i><\/b> Children (&#x3c;24 months) with ONH (<i>n<\/i> = 146; 87% bilateral) underwent baseline MRI and annual examinations and hormonal testing. Hypopituitarism status at age 5 years was classified. <b><i>Results:<\/i><\/b> A total of 74% had brain malformation(s). Hypopituitarism (69%) was not associated with brain malformations (<i>p<\/i> = 0.351); this persisted after adjusting for the laterality of ONH and the timing of MRI (<i>p<\/i><sub>adj<\/sub> = 0.869). No association was noted for absent septum pellucidum (38%; <i>p<\/i> = 0.073), corpus callosum abnormality (51%; <i>p<\/i> = 0.625), and major malformations (22%; <i>p<\/i> = 0.407). A malformation conferred a positive predictive value of 71% (95% CI: 62%, 80%), and a negative predictive value of 37% (95% CI: 22%, 54%). Overall, 10% (<i>n<\/i> = 15) of the cohort presented with a triad of absent septum pellucidum, corpus callosum abnormality, and other major malformation; only half (<i>n<\/i> = 8) of these had hypopituitarism. All 13 subjects with pituitary malformations manifested hypopituitarism, conferring predictive values of 100% (positive) and 34% (negative). <b><i>Conclusions:<\/i><\/b> Hypopituitarism and brain malformations are highly prevalent, but have unrelated associations with ONH. Brain MRI in infants and toddlers with ONH is an unreliable screen for hypopituitarism risk.<\/jats:p>","DOI":"10.1159\/000479029","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T11:22:41Z","timestamp":1503400961000},"page":"251-257","source":"Crossref","is-referenced-by-count":15,"title":["Brain Malformations Do Not Predict Hypopituitarism in Young Children with Optic Nerve 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