{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:58:49Z","timestamp":1781931529832,"version":"3.54.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To report a patient who presented with a conjunctival tumour as a first sign of distant metastasis of cutaneous melanoma. The patient was treated successfully with BRAF\/MEK-inhibitors and anti-PD-1 antibodies. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Clinical and histopathological examination of the conjunctival lesion. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; A 74-year-old man was referred to our hospital with a pigmented conjunctival tumour, 5 months after having been diagnosed with cutaneous melanoma on his right scapula with loco-regional axillary lymph node metastases. The conjunctival lesion was excised and showed a BRAF V600E mutation. Histopathology showed a melanoma with characteristics suspicious for metastasis, as the lesion did not have a relation with the overlying epithelium. Systemic screening showed multiple distant metastases of the cutaneous melanoma in spleen, liver, and bone. Systemic treatment with the combination of a BRAF-inhibitor (dabrafenib) and MEK-inhibitor (trametinib) was started and followed by a switch to an anti-PD-1 antibody (pembrolizumab). Twenty-two months later, the patient is alive and in good clinical health. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Conjunctival metastases of cutaneous melanoma may mimic primary conjunctival melanoma. A good medical history and systemic work-up are required to differentiate these diseases. Identification of the proper diagnosis including mutation analysis is crucial, allowing patients to benefit from newly introduced treatment strategies for metastatic cutaneous melanoma.<\/jats:p>","DOI":"10.1159\/000479114","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T21:01:33Z","timestamp":1504213293000},"page":"107-111","source":"Crossref","is-referenced-by-count":12,"title":["Conjunctival Metastasis of a Cutaneous Melanoma"],"prefix":"10.1159","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-0859","authenticated-orcid":false,"given":"Niels J.","family":"Brouwer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Marinkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Jochems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen W.","family":"Kapiteijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd G.","family":"van Duinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara I.","family":"Haeseker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine J.","family":"Jager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorius P.M.","family":"Luyten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20079"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.05.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1113"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.07.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.06.021"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1586\/17469899.2014.921119"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70872-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.8.928b"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2014.04.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32770-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.04.020"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.218"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000309222"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2000.166"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000055205"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200412000-00003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0163"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000584"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2657-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9570.1000322"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:42:33Z","timestamp":1745426553000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000479114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,1]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,22]]},"published-print":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000479114","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"value":"2296-4681","type":"print"},{"value":"2296-4657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,1]]}}}