{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:35:00Z","timestamp":1790062500160,"version":"4.0.1"},"reference-count":7,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Clinical diagnosis of Creutzfeldt-Jakob disease (CJD) can be supported by the analysis of Tau and 14-3-3 in the cerebrospinal fluid (CSF). In this short report, we report about a retrospective analysis performed on 2,296 routinely collected CSF samples, and 44 samples with a ratio of phosphoTau181\/Tau &lt;0.075 were selected. Analysis was performed with a novel 14-3-3 gamma CircuLex Elisa. We show that control levels were around 6,000 AU\/mL and samples from Alzheimer patients were not different from those collected from healthy controls. Four cases of verified CJD had 14-3-3 CSF levels of &gt;100,000 AU\/mL, while 10 out of 12 suspected CJD samples with 14-3-3 CSF levels between 50,000-100,000 AU\/mL were CJD positive. All samples with 14-3-3 levels between 15,000 and 50,000 AU\/mL were not CJD cases but disorders with complex neuropathology. In conclusion, our data suggests that in CSF samples with a phospho-Tau-181\/Tau ratio &lt;0.075 CSF levels of 14-3-3 should be analyzed. Our data suggests a very high risk for CJD with 14-3-3 levels above 100,000 AU\/mL and a probable diagnosis of CJD based on laboratory parameters above 50,000 AU\/mL.<\/jats:p>","DOI":"10.1159\/000479115","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T21:01:44Z","timestamp":1501016504000},"page":"243-245","source":"Crossref","is-referenced-by-count":8,"title":["Cerebrospinal Fluid Levels of 14-3-3 Gamma: What Does It Tell Us About Sporadic Creutzfeldt-Jakob Disease?"],"prefix":"10.1159","volume":"100","author":[{"given":"Christian","family":"Humpel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Benke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2010.09.007"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.12.023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000230159.67128.00"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151111"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826d5fc3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-120"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.057"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:42:34Z","timestamp":1745426554000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000479115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":7,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2017,11,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000479115","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}