{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T22:14:16Z","timestamp":1786227256464,"version":"build-2736575974"},"reference-count":23,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The difficult course of patients with myasthenia gravis (MG) with anti-muscle-specific tyrosine kinase antibodies (MuSK) has been emphasized. However, no clear information is available on patients who have a benign course. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This study was aimed at comparing patients with favorable (minimal manifestations [MM] or better) and unfavorable outcomes to determine whether excellent response to corticosteroid (CS) treatment within 3 months (good response-3 months) has any predictive effect on the prognosis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Forty-six percent of 46 patients had a favorable outcome at year 3 and 54% at final follow-up. The major finding of this study was its high predictive value with good response-3 months. Those with good response-3 months had significantly more favorable outcome as compared to those without at year 3. The positive predictive value of good response-3 months was high (89% at year 3 and 84% at final follow-up). The negative predictive value diminished from 85% at year 3 to 67% at final follow-up due to increasing number of patients improving in the long run. Overall, 33% of the patients had a benign course with good response-3 months and no major exacerbations until the end of follow-up. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Excellent response to CSs within 3 months appears to predict a favorable outcome in MuSK-MG.<\/jats:p>","DOI":"10.1159\/000479228","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T21:01:24Z","timestamp":1505422884000},"page":"137-142","source":"Crossref","is-referenced-by-count":4,"title":["Prompt Response to Prednisone Predicts Benign Course in MuSK-MG"],"prefix":"10.1159","volume":"78","author":[{"given":"Ozlem","family":"Gungor-Tuncer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuslat","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Toker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guher","family":"Saruhan-Direskeneli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim","family":"Gulsen-Parman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piraye","family":"Oflazer-Serdaroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feza","family":"Deymeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7963-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06781.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2009.5.2.53"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182407982"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000254620.45529.97"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22006"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21533"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b907b"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.05.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150316"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903518107"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.1.25"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20950"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg223"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833c0982"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002790"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150587.71497.B6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20386"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03019.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.052415"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.314"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:43:24Z","timestamp":1745426604000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000479228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":23,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2017,9,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000479228","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}