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Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Appendage Disord"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Observations on the Laron syndrome originally offered the opportunity to explore the effect of insulin-like growth factor 1 (IGF-1) deficiency on human hair growth and differentiation. According to its expression in the dermal hair papilla, IGF-1 is likely involved in reciprocal signaling. It has been shown to affect follicular proliferation, tissue remodeling, and the hair growth cycle, as well as follicular differentiation, identifying IGF-1 signaling as an important mitogenic and morphogenetic regulator in hair follicle biology. Of all the cytokines or growth factors that have been postulated to play a role in hair follicles, ultimately IGF-1 is known to be regulated by androgens. Accordingly, dermal papillary cells from balding scalp follicles were found to secrete significantly less IGF-1 than their counterparts from nonbalding scalp follicles. Herein, hypotrichosis in primary growth hormone deficiency, and a lack of response of female and male androgenetic-type alopecia to treatment with topical minoxidil and oral finasteride in patients who had undergone surgical resection of the pituitary gland, provide further evidence for an effect of IGF-1 on hair growth and alopecia.<\/jats:p>","DOI":"10.1159\/000479333","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T08:51:37Z","timestamp":1503478297000},"page":"90-95","source":"Crossref","is-referenced-by-count":57,"title":["Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia"],"prefix":"10.1159","volume":"4","author":[{"given":"Ralph M.","family":"Tr\u00fceb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031033"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011153232002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.12.6283"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91594-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000077839"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410706"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640241"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70383-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23946.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050086"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23946.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12040"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.42.385"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.388"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2147\/ciia.2006.1.2.121"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.05.003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(04)63006-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001845"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12339"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14529"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12331"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1303571"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04441.x"}],"container-title":["Skin Appendage Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:43:56Z","timestamp":1745426636000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000479333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,4,17]]},"published-print":{"date-parts":[[2018,4,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000479333","archive":["Portico"],"relation":{},"ISSN":["2296-9195","2296-9160"],"issn-type":[{"value":"2296-9195","type":"print"},{"value":"2296-9160","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}