{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:28:40Z","timestamp":1745468920861,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Adenoid cystic carcinoma (ACC) is a rare form of adenocarcinoma, which is a broad term describing any cancer that begins in the glandular tissues. It can be found in the head and neck. We report a patient with recurrent ACC arising from the submandibular gland, treated with 100 mg\/m&lt;sup&gt;2&lt;\/sup&gt; nedaplatin every 4 weeks. Although our patient\u2019s lactate dehydrogenase levels, which is produced by ACC, showed a rising trend throughout the treatment, the level decreased for approximately 2 weeks immediately after administration of nedaplatin every 4 weeks. Thus, there is a possibility that the agent may be effective. Complications such as anorexia and nausea were observed, but they were tolerated and manageable. Nedaplatin may be considered as a supportive agent during palliative therapy for patients with ACC. More clinical trials regarding nedaplatin are necessary, as this study may indicate that a medical approach works well for ACC.<\/jats:p>","DOI":"10.1159\/000479677","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T08:51:45Z","timestamp":1503478305000},"page":"783-789","source":"Crossref","is-referenced-by-count":0,"title":["Nedaplatin as a Single-Agent Chemotherapy May Support Palliative Therapy for Patients with Adenoid Cystic Carcinoma: A Case Report"],"prefix":"10.1159","volume":"10","author":[{"given":"Hiroyuki","family":"Hirakawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Kiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiteru","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro\u00a0","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1043\/2009-0527-RS.1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S35785"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1056-z"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq196"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2014.952046"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00305-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800801)46:3<452::AID-CNCR2820460305>3.0.CO;2-Z"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010770"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010201)91:3<541::AID-CNCR1032>3.0.CO;2-Y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058665"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20327"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2015.504"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2002.34.5.339"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-110"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479677","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479677","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:47:31Z","timestamp":1745426851000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000479677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,9,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000479677","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}