{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:24:02Z","timestamp":1789989842940,"version":"4.0.1"},"reference-count":30,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate the occurrence of abnormally elevated values of biomarkers of growth hormone (GH) action in short children on recombinant human GH (rhGH) therapy. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Sixty-three prepubertal short children were examined: 31 with GH deficiency (GHD), 25 small for gestational age (SGA), and 9 with Turner syndrome (TS). The main outcomes were the following: standard deviation score (SDS) values of IGF-I, IGFBP-3, and IGF-I\/IGFBP-3 molar ratio before, at the 1st and at the 2nd year on rhGH and \u0394height (Ht)-SDS to evaluate GH treatment efficacy (adequate 1st-year \u0394Ht SDS: &amp;#x3e;0.4 SDS for GHD and &amp;#x3e;0.3 SDS for non-GHD). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Seventy-eight percent of GHD, 78% of SGA and 55% of TS children had adequate 1st-year \u0394Ht SDS. In GHD, 88% of IGF-I SDS and IGFBP-3 SDS that were \u2264\u20132.0 SDS at baseline normalized on treatment. Abnormal IGF-I values &amp;#x3e;+2.0 SDS were observed in 52% of SGA and in 55% of TS patients on rhGH. Within each group, the IGF-I\/IGFBP-3 molar ratio increased significantly from pretreatment and throughout therapy, remaining within normal range for most patients. \u0394IGF-I\/IGFBP-3 molar ratio SDS were significantly higher in children with an adequate response (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.01). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Non-GHD groups presented markedly elevated concentrations of GH biomarkers on rhGH and normal IGF-I\/IGFBP-3 molar ratio in most patients. Since there is a lack of consensus regarding the molar ratio usefulness, we think that interventions towards a more physiological IGF-I serum profile should be implemented.<\/jats:p>","DOI":"10.1159\/000479691","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T21:02:08Z","timestamp":1505854928000},"page":"354-363","source":"Crossref","is-referenced-by-count":15,"title":["Circulating IGF-I, IGFBP-3 and the IGF-I\/IGFBP-3 Molar Ratio Concentration and Height Outcome in Prepubertal Short Children on rhGH Treatment over Two Years of Therapy"],"prefix":"10.1159","volume":"88","author":[{"given":"Mar\u00eda\u00a0Gabriela","family":"Ballerini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Braslavsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula\u00a0Alejandra","family":"Scaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Keselman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u00a0Eugenia","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda\u00a0Ver\u00f3nica","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio\u00a0Mario","family":"Domen\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor\u00a0Guillermo","family":"Jasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Bergad\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u00a0Gabriela","family":"Ropelato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,9,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.11.3990"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307228"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000452150"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1995"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2882"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01105.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v1i5.240"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12408"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.3.744"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370132"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2004.06.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.11.6928"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0505"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000439051"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-11-66"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2013.08.003"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04420.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1471"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0343-y"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.2.7688291"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1377"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3363"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2014.02.001"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000737"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1002"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2015.06.003"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2004.17.5.749"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(81)90052-4"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.12.7017"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1590\/S0325-00752009000500007"}],"container-title":["Hormone 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