{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:54:07Z","timestamp":1770836047244,"version":"3.50.1"},"reference-count":52,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background\/Aims: <\/i><\/b>We aimed to clarify whether cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1) genotypes were associated with certain histological findings and endoscopical appearances based on Kyoto classification. <b><i>Methods: <\/i><\/b>We enrolled 285 <i>Helicobacter pylori<\/i>-infected gastritis patients. Genotypes of <i>COX-2 <\/i>1195, <i>COX-2 <\/i>1290, <i>mPGES-1<\/i>, interleukin-1\u03b2 (<i>IL-1\u03b2<\/i>) 511 and tumour necrosis factor-\u03b1 (<i>TNF-\u03b1<\/i>) 308 were analyzed. Genotyping was performed by polymerase chain reaction. Endoscopic appearances and histological assessment were determined by using Kyoto classification, operative link on gastritic intestinal metaplasia assessment and the updated Sydney system. <b><i>Results:<\/i><\/b> There was a significant (<i>p<\/i> = 0.027) relationship between the <i>IL-1\u03b2 <\/i>511 C-carrier and histological gastric inflammation in <i>H. pylori<\/i>-infected gastritis patients. There was a significant (<i>p<\/i> = 0.009) correlation between the <i>COX-2<\/i> 1195 G-carrier genotype and histological intestinal metaplasia in the gastric antrum of <i>H. pylori<\/i>-infected gastritis patients and gastric xanthoma (<i>p<\/i> = 0.027). The <i>COX-2 <\/i>1195 G-carrier genotype was also significantly (<i>p<\/i> = 0.038) associated with the score of endoscopic intestinal metaplasia based on Kyoto classification. The <i>mPGES-1<\/i> genotype was significantly (<i>p<\/i> = 0.002) associated with endoscopic swelling of area. <b><i>Conclusion:<\/i><\/b> Our results suggest that in Japan, there exists a significant correlation between the <i>COX-2<\/i> 1195 G-carrier genotype and intestinal metaplasia in histological and endoscopic findings based on Kyoto classification in <i>H. pylori<\/i>-infected gastric mucosa.<\/jats:p>","DOI":"10.1159\/000479864","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T21:01:21Z","timestamp":1506373281000},"page":"173-183","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Cyclooxygenase-2 1195 G-Carrier Genotype Associated with Intestinal Metaplasia and Endoscopic Findings Based on Kyoto Classification"],"prefix":"10.1159","volume":"96","author":[{"given":"Yasuhiro","family":"Kodaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Futagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Tatsuguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamawaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Kawagoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobue","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nagoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuuta","family":"Maruki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya","family":"Gudis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choitsu","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10068"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81433-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1943"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70254-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9098(200101)76:1<26::AID-JSO1005>3.0.CO;2-A"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i4.674"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.05.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.03.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305108200"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003504200"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2614"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.07.042"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/den.12286"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.12.029"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000368807"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000441742"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021894"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.021"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073213"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70422-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1279-4"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70410-0"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.6.743"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.6.782"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01070.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3867"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032482"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31902"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.01.020"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2012.6.3.321"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-9924-0"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00137.2003"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s005350200016"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01211.x"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701673"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1159\/000374106"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34156"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.07.042"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213290200"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-1032-3"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.04.020"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.1.469"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203618200"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04277.x"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03192.x"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12291"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2272"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64586-5"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/479864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:50:00Z","timestamp":1745427000000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000479864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,10,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000479864","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}