{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:10:05Z","timestamp":1745428205368,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>The B-cell receptor signaling pathway is important in the lymphomagenesis of many lymphomas, including marginal zone lymphoma (MZL). Herein we describe a case of extranodal MZL refractory to multiple lines of therapy. The presence of an IgM paraprotein prompted further evaluation, and the patient was found to have an MYD88&lt;sup&gt;L265P&lt;\/sup&gt; mutation. Treatment with ibrutinib led to a dramatic response with prompt resolution of symptoms and significant improvement in measurable sites of disease. The excellent response to ibrutinib in our patient with MYD88&lt;sup&gt;L265P&lt;\/sup&gt;-mutated refractory MZL supports a biological rationale for its use.<\/jats:p>","DOI":"10.1159\/000480292","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T21:03:23Z","timestamp":1505250203000},"page":"813-818","source":"Crossref","is-referenced-by-count":4,"title":["Dramatic Response with Single-Agent Ibrutinib in Multiply Relapsed Marginal Zone Lymphoma with MYD88L265P Mutation"],"prefix":"10.1159","volume":"10","author":[{"given":"Ryan\u00a0C.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjana\u00a0H.","family":"Advani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1200\/JCO.1998.16.8.2780"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1097\/PAS.0000000000000411"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.3816\/CLM.2005.n.003"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1182\/blood-2014-01-550905"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1056\/NEJMoa1200710"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1182\/blood-2012-12-475111"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1038\/nature09671"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1056\/NEJMoa1501548"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1182\/blood-2016-01-643569"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.5858\/arpa.2014-0322-OA"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1038\/modpathol.2014.120"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016\/j.semcancer.2013.09.001"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1182\/blood.V98.13.3745"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1182\/blood-2005-09-3679"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1007\/s00277-017-2968-z"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1182\/blood-2016-10-747345"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/480292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/480292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/480292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:53:21Z","timestamp":1745427201000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000480292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,1,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000480292","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2017,9,12]]}}}