{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:58:52Z","timestamp":1785473932555,"version":"3.56.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Patiromer is a sodium-free, nonabsorbed, potassium binder approved for treatment of hyperkalemia. This open-label study compares the efficacy and safety of patiromer administered <i>without food<\/i> versus <i>with food<\/i>. <b><i>Methods:<\/i><\/b> Adults with hyperkalemia (potassium \u22655.0 mEq\/L) were randomized (1:1) to receive patiromer once daily <i>without food<\/i> or <i>with food<\/i> for 4 weeks. The dosage was adjusted (maximum: 25.2 g\/day) using a prespecified titration schedule to achieve and maintain potassium within a target range (3.8-5.0 mEq\/L). The primary efficacy endpoint was the proportion of patients with serum potassium in the target range at either week 3 or week 4. Safety was assessed by adverse events (AEs) and laboratory testing. <b><i>Results:<\/i><\/b> Efficacy was evaluated in 112 patients; 65.2% were \u226565 years of age, 75.9% had chronic kidney disease, and 82.1% had diabetes. Baseline mean serum potassium was similar in the <i>without-food<\/i> (5.44 mEq\/L) and <i>with-food<\/i> (5.34 mEq\/L) groups. The primary endpoint was achieved by 87.3% (95% CI 75.5-94.7) and 82.5% (95% CI 70.1-91.3) of patients in the <i>with-food<\/i> and <i>without-food <\/i>groups, respectively; least squares mean changes in serum potassium from baseline to week 4 were -0.65 and -0.62 mEq\/L, respectively (<i>p<\/i> < 0.0001). The most common AEs were diarrhea and constipation. Serum K<sup>+<\/sup> remained \u22653.5 mEq\/L in all patients; 5 patients developed serum magnesium <1.4 mg\/dL, including 4 whose baseline magnesium was below the lower limit of normal. <b><i>Conclusion:<\/i><\/b> Patiromer is equally effective and well tolerated when taken <i>without food<\/i> or <i>with food<\/i>, thereby offering the potential for dosing flexibility.<\/jats:p>","DOI":"10.1159\/000481270","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T21:01:49Z","timestamp":1507842109000},"page":"323-332","source":"Crossref","is-referenced-by-count":39,"title":["Patiromer Lowers Serum Potassium When Taken without Food: Comparison to Dosing with Food from an Open-Label, Randomized, Parallel Group Hyperkalemia Study"],"prefix":"10.1159","volume":"46","author":[{"given":"Pablo E.","family":"Pergola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Spiegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Weir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31829e8776"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520420066040"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010713"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604113341502"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.031"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011161"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2017.23.4-a.s2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.00071.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2012.717478"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.03.007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.014281"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410853"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.402"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.7446"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0273"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.09.023"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.300268"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:00:34Z","timestamp":1745427634000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000481270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,10,24]]},"published-print":{"date-parts":[[2017,10,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000481270","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}