{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:40:52Z","timestamp":1783618852296,"version":"3.55.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; Multiple myeloma (MM) is characterized by the occurrence of osteolytic lesions. MM treatment usually involves antiresorptive drugs (mainly bisphosphonates). &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; A patient with an MM presented osteolytic lesions of the mandible. Extraction of teeth 45 and 46 was performed 5 years after the diagnosis of periodontitis. Four months later, osteonecrosis of the jaw (ONJ) was diagnosed at the extraction site. X-ray showed an extension of osteolytic lesions on the right side, close to the extraction site, without modification of the lesions on the left side. Two months later, a curettage was performed because of a painful bone sequestration. X-ray showed an extension of the osteolytic lesions on the right side. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Histological analysis found a vascularized plasmacytoma of the soft tissues around the ONJ. Analysis of the bone showed mixed lesions with osteonecrotic areas and living bone resorbed by active osteoclasts surrounding a plasmacytoma. The surface area of the osteolytic foci has considerably increased only close to the extraction site. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Tooth extraction triggered an ONJ associated with bisphosphonate treatment. However, it also seemed to induce a considerable proliferation of plasma cells at the extraction site; we hypothesize that it is due to the increase in bone remodeling related to the surgical trauma.<\/jats:p>","DOI":"10.1159\/000481425","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T22:03:50Z","timestamp":1512511430000},"page":"201-207","source":"Crossref","is-referenced-by-count":5,"title":["Tooth Extraction Locally Stimulates Proliferation of Multiple Myeloma in a Patient with Mandibular Localizations"],"prefix":"10.1159","volume":"138","author":[{"given":"Jean-Daniel","family":"K\u00fcn-Darbois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9onie","family":"Quenel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sma\u00efl","family":"Badja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Chappard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.336"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30189-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.morpho.2015.03.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.12.1909"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002386"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4317\/jced.52832"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030847"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2015.69.367-370"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.07.010"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.063007.134350"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-014-0688-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-008-0012-z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3839"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(52)90316-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(69)90357-0"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.03.007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091960210"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650060704"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.08.007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.morpho.2015.01.003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00196-0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.02.131"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2017.01.009"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197202)29:2<466::AID-CNCR2820290234>3.0.CO;2-M"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930560311"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10296"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.morpho.2011.02.004"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159\/000354830"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159\/000354833"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:01:49Z","timestamp":1745427709000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000481425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,2,5]]},"published-print":{"date-parts":[[2018,1,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000481425","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}