{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T04:25:45Z","timestamp":1749788745991,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Objective:<\/i><\/b> This study aimed to determine the aryl hydrocarbon receptor (AhR) and transforming growth factor beta 1 (TGF-\u03b21) expression levels in chronic rhinosinusitis (CRS) and their possible correlation with allergic state and tissue remodeling. <b><i>Methods:<\/i><\/b> Patients were enrolled and divided into the following groups: CRS without nasal polyps (NP) without allergic rhinitis (AR) (CRSsNPsAR; <i>n<\/i> = 20), CRS with NP with AR (CRSwNPwAR; <i>n<\/i> = 20), CRS with NP without AR (CRSwNPsAR; <i>n<\/i> = 20), and controls (<i>n<\/i> = 15). Tissue samples were analyzed by Masson trichrome staining for collagen, while the location and expression of AhR and TGF-\u03b21 were analyzed by immunohistochemistry, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and Western blotting. <b><i>Results:<\/i><\/b> The collagen amounts as well as AhR and TGF-\u03b21 mRNA and protein expression levels were significantly increased in the CRSsNPsAR group compared with the CRSwNP (CRSwNPsAR and CRSwNPwAR) samples (<i>p<\/i> < 0.01). However, higher collagen amounts (<i>p<\/i> < 0.05) and higher TGF-\u03b21 (<i>p<\/i> < 0.05) but lower AhR expression levels (<i>p<\/i> < 0.05) were detected in the CRSwNPwAR versus the CRSwNPsAR patients. Both AhR and TGF-\u03b21 expression were positively correlated with the collagen level in CRS samples (<i>p<\/i> < 0.01). <b><i>Conclusions:<\/i><\/b> Elevated AhR expression may be involved in the progression of tissue remodeling in CRSsNPsAR similar to TGF-\u03b21 expression. Conversely, lower AhR expression may be involved in allergic reactions in CRSwNPwAR.<\/jats:p>","DOI":"10.1159\/000481510","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T22:05:55Z","timestamp":1511906755000},"page":"295-305","source":"Crossref","is-referenced-by-count":3,"title":["Differential Expression of the Aryl Hydrocarbon Receptor and Transforming Growth Factor Beta 1 in Chronic Rhinosinusitis with Nasal Polyps with Allergic Rhinitis"],"prefix":"10.1159","volume":"79","author":[{"given":"Lu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangju","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000338799"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino50E2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01318.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02880.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128564"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2003.3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/all.12403"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.04.013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9751-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e318201d831"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000430284"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01635.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009201107"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445228"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25383"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2011.10.019"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1126\/science.7732381"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct188"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.04.012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.09.031"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.04.056"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00323-07"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.12.025"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481510","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:02:40Z","timestamp":1745427760000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000481510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,3,13]]},"published-print":{"date-parts":[[2018,2,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000481510","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"type":"print","value":"0301-1569"},{"type":"electronic","value":"1423-0275"}],"subject":[],"published":{"date-parts":[[2017]]}}}