{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:37:54Z","timestamp":1778719074058,"version":"3.51.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Serum 1,5-anhydroglucitol (1,5-AG) levels are a measure that provides information on daily glycemic variations. We evaluated whether 1,5-AG could be a possible marker of acute ischemic stroke (AIS) or transient ischemic attacks (TIA) in patients with diabetes mellitus (DM). <b><i>Methods:<\/i><\/b> We retrospectively reviewed electronic medical records of 5,294 AIS\/TIA patients. Of the 5,294, 1,898 had diabetes and in 1,246, serum 1,5-AG levels were measured (group S). Group S was divided into 2 subgroups: hemoglobin A1c (HbA1c) &#x3c;7% (S-low) and &#x3e;7% (S-high). As controls, 394 outpatients with diabetes (group C) without AIS\/TIA were likewise divided into subgroups, C-low and C-high according to HbA1c level. In each HbA1c subgroup, the association between serum 1,5-AG (\u226514 vs. &#x3c;14 \u00b5g\/mL) and stroke was examined using multivariable logistic regression (MLR) with stepwise variable selection. In model 1, the OR and 95% CI was examined adjusted for age and gender. Known risk factors for stroke; hypertension, dyslipidemia, alcohol consumption, smoking, and estimated glomerular filtration rate were included in model 2. <b><i>Results:<\/i><\/b> Overall, serum 1,5-AG levels were lower in group S than in group C. Serum 1,5-AG levels were low in subgroups S-high and C-high, showing no differences in mean values. However, mean serum 1,5-AG levels in S-low was statistically lower than that in C-low. MLR analysis showed that the OR for low (&#x3c;14 \u00b5g\/mL) 1,5-AG for stroke was statistically significant only in well-controlled diabetes (OR [95% CI] 2.19 [1.54\u20133.10]) in model 1 and (2.26 [1.56\u20133.28]) model 2. <b><i>Conclusions:<\/i><\/b> Low serum 1,5-AG levels could be a possible marker for AIS\/TIA risk in patients with well-controlled DM.<\/jats:p>","DOI":"10.1159\/000481626","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T21:01:59Z","timestamp":1509051719000},"page":"325-329","source":"Crossref","is-referenced-by-count":10,"title":["Serum 1,5-Anhydroglucitol: Risk Factor of Acute Ischemic Stroke and Transient Ischemic Attack in Well-Controlled Diabetes"],"prefix":"10.1159","volume":"44","author":[{"given":"Yuji","family":"Shiga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhei","family":"Kanaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Takeshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Takemaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Shimoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Fujikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Nishigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60150-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.564708"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i1.17"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.1.52"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.02.033"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.08.016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0607"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4909"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)04311-6"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:03:37Z","timestamp":1745427817000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000481626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":12,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2017,12,5]]},"published-print":{"date-parts":[[2017,12,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000481626","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}