{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:23:54Z","timestamp":1791959034475,"version":"4.3.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Aim:<\/i><\/b> To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. <b><i>Methods:<\/i><\/b> This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21\u201330. <b><i>Results:<\/i><\/b> A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats\/min, <i>p<\/i> &#x3c; 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats\/min, <i>p<\/i> &#x3c; 0.01) without affecting BP. A significant HR rise (+4.9 beats\/min, <i>p<\/i> &#x3c; 0.05) and SBP reduction (\u20133.8 mm Hg, <i>p<\/i> &#x3c; 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats\/min, <i>p<\/i> &#x3c; 0.05), while BP values resulted unaffected. <b><i>Conclusions:<\/i><\/b> In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.<\/jats:p>","DOI":"10.1159\/000481665","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T22:01:39Z","timestamp":1509487299000},"page":"86-91","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers"],"prefix":"10.1159","volume":"101","author":[{"given":"Alfredo","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Bosone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Zoppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"D'Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascia","family":"Ghiotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Guaschino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cotta\u00a0Ramusino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Fogari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(64)90070-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(90)90040-W"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(71)90054-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(76)90239-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00882-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199307000-00009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.63.135"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2003.930103.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01335-8"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(88)90533-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(92)90101-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.10.054"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-003-0074-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1993.tb09544.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200205000-00008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2007001800009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-015-0488-3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.05.918"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1996.03642.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.150535"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000668"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0956-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.08.014"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:03:56Z","timestamp":1745427836000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000481665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":23,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2017,12,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000481665","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,31]]}}}