{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:29:58Z","timestamp":1762504198384,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> Many adolescents with type 2 diabetes (T2D) have rapid deterioration of glycemic control on metformin monotherapy within 2 years of diagnosis. <b><i>Methods:<\/i><\/b> Enrollment data from the Pediatric Diabetes Consortium T2D Registry were used to categorize 276 youth with a T2D duration \u22652 years into two groups: (1) participants with HbA<sub>1c<\/sub> &#x3c;7.5% on metformin monotherapy (group 1, <i>n<\/i> = 75) and (2) participants treated with insulin \u00b1 metformin (group 2, <i>n<\/i> = 201). The characteristics of the groups were compared. <b><i>Results:<\/i><\/b> At enrollment, groups 1 and 2 did not differ in age (16.2 vs. 16.8 years) or BMI percentile (99 vs. 98%); group 2 had higher HbA<sub>1c<\/sub> (9.9% [85 mmol\/mol] vs. 5.9% [41 mmol\/mol], <i>p<\/i> &#x3c; 0.001). Lower HbA<sub>1c<\/sub> and metformin monotherapy at diagnosis were associated with a greater likelihood of adequate control with metformin alone (<i>p<\/i> &#x3c; 0.001). In multivariable analysis, HbA<sub>1c<\/sub> at diagnosis (<i>p<\/i> = 0.001) and diabetes duration (<i>p<\/i> = 0.009) were associated with adequate control on metformin. The HbA<sub>1c<\/sub> trajectory after diagnosis was worse in group 2. <b><i>Conclusion:<\/i><\/b> Durable metabolic control of T2D with metformin monotherapy is most likely in youth presenting with lower HbA<sub>1c<\/sub> and with shorter diabetes duration, independent of age, race-ethnicity, and BMI. Elevated HbA<sub>1c<\/sub> levels in those on insulin therapy highlight the importance of early diagnosis and a better understanding of glycemic control barriers.<\/jats:p>","DOI":"10.1159\/000481687","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T23:02:12Z","timestamp":1509577332000},"page":"47-55","source":"Crossref","is-referenced-by-count":25,"title":["Initial Presentation of Type 2 Diabetes in Adolescents Predicts Durability of Successful Treatment with Metformin Monotherapy: Insights from the Pediatric Diabetes Consortium T2D Registry"],"prefix":"10.1159","volume":"89","author":[{"given":"Fida","family":"Bacha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin\u00a0L.","family":"Gal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Kollman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William\u00a0V.","family":"Tamborlane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgeanna\u00a0J.","family":"Klingensmith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Manseau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy\u00a0W.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for\u00a0the\u00a0Pediatric\u00a0Diabetes\u00a0Consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2007.00330.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12281"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12280"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12264"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2012.00915.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2393"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109333"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-er09"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12377"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S014"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2011.00841.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1392"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0848"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2229"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0574"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481687","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:04:01Z","timestamp":1745427841000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000481687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,2,2]]},"published-print":{"date-parts":[[2018,1,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000481687","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2017,10,31]]}}}