{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:22:42Z","timestamp":1784258562042,"version":"3.55.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Teicoplanin is a glycopeptide antibiotic currently used for the treatment of methicillin-resistant <i>Staphylococcus aureus<\/i>. The need for therapeutic drug monitoring of teicoplanin has been increasingly highlighted as important. It is generally accepted that whereas a plasma trough concentration (C<sub>min<\/sub>) of \u226510 mg\/L is appropriate for the majority of infections, it should exceed 20 mg\/L for severe infections. The target C<sub>min<\/sub> of teicoplanin in patients with febrile neutropenia (FN) has not been reported. The aim of this study was to estimate the target C<sub>min<\/sub> for the treatment of FN in patients with hematological malignancy. <b><i>Methods:<\/i><\/b> In this retrospective, single-center, observational cohort study, the records of 52 hospitalized patients with hematological malignancy who were treated with teicoplanin for FN due to bacteriologically documented or presumptive gram-positive infections were analyzed. <b><i>Results:<\/i><\/b> A significant difference in the first C<sub>min<\/sub> of teicoplanin was observed between the response and nonresponse groups in patients with bacteremia. The areas under the receiver operating characteristic curves were 0.80 for clinical efficacy. The cut-off value of teicoplanin C<sub>min<\/sub> on days 4-6 was 15.2 mg\/L (sensitivity 80.0%, specificity 75.0%). <b><i>Conclusions:<\/i><\/b> The authors propose a target teicoplanin C<sub>min<\/sub> of \u226515.2 mg\/L for FN in patients with hematological malignancy.<\/jats:p>","DOI":"10.1159\/000481725","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T22:01:32Z","timestamp":1511474492000},"page":"29-34","source":"Crossref","is-referenced-by-count":14,"title":["Optimal Trough Concentration of Teicoplanin in Febrile Neutropenic Patients with Hematological Malignancy"],"prefix":"10.1159","volume":"63","author":[{"given":"Yuhki","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Hiramatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Nonoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Kadota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn096"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00341-09"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg147"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.05.012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.6.835"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000381634"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086\/383054"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.11.027"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080434"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.262"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.6.564.34743"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.05.019"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/31.5.755"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-006-0437-z"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:04:11Z","timestamp":1745427851000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000481725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,2,22]]},"published-print":{"date-parts":[[2018,2,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000481725","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]}}}