{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:10:55Z","timestamp":1784592655780,"version":"3.55.0"},"reference-count":35,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord Extra"],"abstract":"<b><i>Objectives:<\/i><\/b> This study aimed to investigate the relationship between cerebrospinal fluid (CSF) S100B astrocyte-derived protein and delirium and to perform stratified analyses according to clinical and CSF markers of dementia. <b><i>Methods:<\/i><\/b> We performed a prospective cohort study in a university hospital setting. The participants were patients admitted for hip fracture (<i>n<\/i> = 98) or for elective surgery (<i>n<\/i> = 50). Delirium was assessed daily perioperatively in hip fracture patients using the Confusion Assessment Method. A consensus-based diagnosis of prefracture dementia was made using all available information. CSF was drawn at the onset of spinal anesthesia. S100B and phosphorylated tau (P-tau) concentrations were measured using electrochemiluminescence immunoassay and enzyme-linked immunosorbent assays, respectively. <b><i>Results:<\/i><\/b> In the hip fracture population (<i>n<\/i> = 98) there was no significant difference in CSF S100B concentrations between patients with ongoing preoperative (i.e., prevalent) delirium (<i>n<\/i> = 36, median [interquartile range] 1.11 \u03bcg\/L [0.91\u20131.29]) and patients who never developed delirium (<i>n<\/i> = 46, 1.08 \u03bcg\/L [0.92\u20131.28], <i>p<\/i> = 0.92). In patients without preoperative delirium, those who developed delirium postoperatively (i.e., incident delirium) (<i>n<\/i> = 16, 1.38 \u03bcg\/L [1.08\u20131.62]) had higher concentrations of S100B than the 46 who never did (<i>p<\/i> = 0.013). This difference was confined to patients with pathological concentrations of P-tau (\u226560 ng\/L, <i>n<\/i> = 38). We also found that P-tau and S100B were correlated in CSF in the elective surgery patients. <b><i>Conclusions:<\/i><\/b> CSF S100B was elevated in patients with incident delirium who also had pathological levels of the Alzheimer disease biomarker P-tau, suggesting vulnerability caused by a preexisting process of astrocytic activation and tau pathology.<\/jats:p>","DOI":"10.1159\/000481853","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T22:02:37Z","timestamp":1510264957000},"page":"374-385","source":"Crossref","is-referenced-by-count":41,"title":["Cerebrospinal Fluid S100B and Alzheimer\u2019s Disease Biomarkers in Hip Fracture Patients with Delirium"],"prefix":"10.1159","volume":"7","author":[{"given":"Karen\u00a0Roksund","family":"Hov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Bolstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane-Victoria","family":"Idland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3930-4354","authenticated-orcid":false,"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1890-4193","authenticated-orcid":false,"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrukh\u00a0A.","family":"Chaudhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frede","family":"Frihagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"R\u00e6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torgeir\u00a0Bruun","family":"Wyller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0441-6700","authenticated-orcid":false,"given":"Leiv\u00a0Otto","family":"Watne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001772"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60688-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.05.019"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu022"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws190"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a4129a"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.3423"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20184"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10552"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07612.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2326"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-9-21"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.3.645"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14470"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000130613.35877.75"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2012.12.024"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13696"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq090"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/539581"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01697-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00159.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-63"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-12-36"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-113-12-941"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(96)00316-8"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1159"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70355-6"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00048-1"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01257-0"}],"container-title":["Dementia 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