{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:24:40Z","timestamp":1789669480598,"version":"4.0.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and\/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shrimp-allergic subjects from subjects that are sensitized but tolerant. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to evaluate the role of IgE to the different shrimp and mite allergens in distinguishing shrimp challenge-positive from challenge-negative patients. Subjects with suspected hypersensitivity reactions to shrimp, positive skin prick tests (SPTs), and\/or anti-shrimp IgE were submitted to open and double-blind placebo-controlled food challenges (DBPCFC). Specific IgE to shrimp, mites, and the recombinants rPen a 1, rDer p 1, 2, and 10 were tested using ImmunoCAP-FEIA. IgE immunoblotting was performed to identify the patients' allergenic profiles. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In total, 13 out of 51 (25.5%) patients with reported reactions to shrimp were truly shrimp&lt;b&gt; &lt;\/b&gt;allergic (7 DBPCFC positive and 6 with documented severe reactions). These patients had significantly higher skin test wheal diameters&lt;b&gt; &lt;\/b&gt;than nonallergic patients,&lt;b&gt; &lt;\/b&gt;as well as higher levels of IgE to rPen a 1 and rDer p 10. HDM-induced asthma and the&lt;b&gt; &lt;\/b&gt;simultaneous presence of anti-nDer p 1, 2, and 10 IgE levels increased the risk of true shrimp allergy. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Food challenge tests are mandatory for the diagnosis of shrimp allergy. Tropomyosin is associated with clinical reactivity. HDM-induced asthma and anti-mite IgE are risk factors for shrimp allergy.<\/jats:p>","DOI":"10.1159\/000481985","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T22:01:31Z","timestamp":1511474491000},"page":"133-143","source":"Crossref","is-referenced-by-count":39,"title":["Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy"],"prefix":"10.1159","volume":"174","author":[{"given":"Laura","family":"Farioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Michelina","family":"Losappio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Pravettoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Micarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Nichelatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Scibilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Mirone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cavallarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lamberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Giuseppe","family":"Balossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elide Anna","family":"Pastorello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.044"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8429-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/all.12423"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02346.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02663.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.02.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2013.7.5.347"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119914"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.01.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.024"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03513.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00466.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90090-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300425"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2008.0139"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01722.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400122"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000602"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.06.002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.5961"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.023"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/481985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:06:51Z","timestamp":1745428011000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000481985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2017,12,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000481985","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}