{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:48:46Z","timestamp":1785034126596,"version":"3.55.0"},"reference-count":36,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; In dialysis and renal transplant patients with secondary and tertiary hyperparathyroidism (HPT), the value of intraoperative parathyroid hormone (ioPTH) during parathyroidectomy (PTX) and its association with long-term PTH levels are unknown. The present study aims at evaluating the relationship of ioPTH with long-term PTH levels post-PTX in dialysis and renal transplant patients in a single-center study. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The ioPTH was measured in 57 dialysis patients (33 females and 24 males) and 18 renal transplant recipients (12 males and 6 females) who underwent PTX from 2005 to 2015 for refractory HPT. Near-total PTX was performed in 56 patients and total PTX with autotransplantation in 20 patients. The PTH monitoring included 3 samples: pre-intubation, 10- and 20-min (pre-ioPTH, 10-ioPTH, and 20-ioPTH) post parathyroid gland excision. Patients were followed up for up to 5 years. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In the dialysis group, the median (25th\u201375th percentile) pre-, 10-, and 20-ioPTH levels were 1,447 pg\/mL (938\u20132,176), 143 pg\/mL (78\u2013244) and 112 pg\/mL (59\u2013153) respectively. In the renal transplant group, pre-, 10-, and 20-ioPTH levels were 273 pg\/mL (180\u2013403), 42 pg\/mL (25\u201372), and 34 pg\/mL (23\u201345) respectively. All patients in the transplant group had a functional kidney transplant at the time of PTX with a median serum creatinine of 1.3 mg\/dL (1.2\u20131.7) and estimated glomerular filtration rate of 55 mL\/min (40\u201360). The median time between renal transplant and PTX surgeries was 22 months (7\u201381). The last median follow-up PTH level was 66 pg\/mL (15\u2013201) in the dialysis group and 54 pg\/mL (17\u201372) in the transplant group (&lt;i&gt;p&lt;\/i&gt;\u00a0= 0.438). The mean time for last PTH post-PTX was 2.3 \u00b1 2.0 years. In both groups, there was no significant difference between 20-ioPTH and any-time post-PTX PTH levels (&lt;i&gt;p&lt;\/i&gt;\u00a0= 0.6 and &lt;i&gt;p&lt;\/i&gt;\u00a0= 0.9). Nineteen patients (25%) were readmitted within 90 days because of hypocalcemia. One patient in the dialysis group was readmitted for post-PTX hematoma evacuation. No patient required repeat PTX because of recurrent HPT that was refractory to medical therapy. Only one dialysis patient required repeat PTX because the first procedure failed. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The 20-ioPTH is a good indicator of long-term PTH levels in dialysis and renal transplant patients. Hypocalcemia is a common complication, particularly in dialysis patients, and it is the main reason for readmission after PTX. Hypoparathyroidism is a potential concern after PTX in dialysis patients.<\/jats:p>","DOI":"10.1159\/000482016","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T22:01:52Z","timestamp":1510264912000},"page":"119-128","source":"Crossref","is-referenced-by-count":25,"title":["Value of Intraoperative Parathyroid Hormone Assay during Parathyroidectomy in Dialysis and Renal Transplant Patients with Secondary and Tertiary Hyperparathyroidism"],"prefix":"10.1159","volume":"138","author":[{"given":"Amr","family":"El-Husseini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Edon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Saxon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.\u00a0Peter","family":"Sawaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12632"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000445204"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5935\/1808-8694.20130088"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/srep26841"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.10.049"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00824.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.2.186"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2003000600006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.02.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001213"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-006-0070-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9648-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21441"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01200.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.01.054"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2017.01.067"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.02.009"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000300012"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh892"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181d8b6ff"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00905-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.188"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001875"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03520414"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174811"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2941-6"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv334"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00972.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.72"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0365-9"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2016.03.012"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv286"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-006-0693-1"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-13-S2-S4"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.123"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2016.1184924"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/482016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/482016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:07:03Z","timestamp":1745428023000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000482016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,9]]},"published-print":{"date-parts":[[2018,2,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000482016","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"publish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