{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:42:37Z","timestamp":1790401357763,"version":"4.1.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Purpose:<\/i><\/b> To evaluate placental function and perfusion in a rat model of preeclampsia infused with L-nitro-arginine methyl ester (L-NAME) by dynamic contrast-enhanced (DCE) MRI using gadolinium chelates. <b><i>Methods:<\/i><\/b> Pregnant female Sprague-Dawley rats were fitted on embryonic day 16 (E16) with subcutaneous osmotic minipumps loaded to deliver, continuously, L-NAME (50 mg\/day per rat; case group) or saline solution (control group). DCE MRI was performed on E19 using gadolinium chelates and a 4.7-T MRI apparatus for small animals. Quantitative analysis was performed using an image software program: placental blood flow (perfusion in mL\/min\/100 mL of placenta) and fractional volume of the maternal vascular placental compartment (ratio between the placental blood volume and the placental volume, Vb in %) were calculated by compartmental analysis. <b><i>Results:<\/i><\/b> A total of 176 placentas (27 rats) were analyzed by DCE MRI (97 cases and 79 controls). The model was effective, inducing intrauterine growth retardation, as there was a significant difference between the two groups for placental weight (<i>p<\/i> &#x3c; 0.01), fetal weight (<i>p<\/i> = 0.019), and fetal length (<i>p<\/i> &#x3c; 0.01). There was no significant difference in placental perfusion between the L-NAME and control groups (140.1 \u00b1 74.1 vs. 148.9 \u00b1 97.4, respectively; <i>p<\/i> = 0.496). There was a significant difference between the L-NAME and control groups for Vb (53 \u00b1 12.9 vs. 46.7 \u00b1 9%, respectively; <i>p<\/i> &#x3c; 0.01). <b><i>Conclusion:<\/i><\/b> In the L-NAME preeclampsia model, placental perfusion is normal and the fractional blood volume is increased, suggesting that preeclampsia is not always expressed as a result of decreased placental perfusion. This highlights the usefulness of MRI for investigating the physiopathology of preeclampsia.<\/jats:p>","DOI":"10.1159\/000484314","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T21:01:21Z","timestamp":1524603681000},"page":"277-284","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of Placental Perfusion in the Preeclampsia L-NAME Rat Model with High-Field Dynamic Contrast-Enhanced 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