{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:13:12Z","timestamp":1791486792539,"version":"4.3.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> There is increasing evidence that exposure to air pollutants, including particulate matter (PM<sub>2.5<\/sub>, PM<sub>10<\/sub>), nitrogen dioxide (NO<sub>2<\/sub>), and sulfur dioxide (SO<sub>2<\/sub>), might aggravate preexisting skin diseases such as eczema and urticaria. Here we investigated if a possible link exists between air pollution and acne vulgaris. We assessed the association between ambient air pollutant concentrations and the number of visits of patients for acne vulgaris to a dermatological outpatient clinic in Beijing, China, from April 1, 2012 to April 30, 2014. <b><i>Methods:<\/i><\/b> In this time period, 59,325 outpatient visits were recorded because of acne vulgaris. Daily air pollution parameters for PM<sub>10<\/sub>, PM<sub>2.5<\/sub>, SO<sub>2<\/sub>, and NO<sub>2<\/sub> were obtained from the Beijing Municipal Environmental Monitoring Center. <b><i>Results:<\/i><\/b> Increased concentrations of ambient PM<sub>2.5<\/sub>, PM<sub>10<\/sub>, and NO<sub>2<\/sub> were significantly associated with increased numbers of outpatient visits for acne vulgaris over the 2 years. These effects could be observed for NO<sub>2<\/sub> in a single-pollutant model and for PM<sub>2.5<\/sub>, PM<sub>10<\/sub>, and NO<sub>2<\/sub> in 2-pollutant models, which are closer to real-life exposure. Of note, these effects were specific because they were not observed for increased SO<sub>2<\/sub> concentrations, which even showed negative correlations in all test models. <b><i>Conclusion:<\/i><\/b> This study provides indirect evidence for a link between acne vulgaris and air pollution.<\/jats:p>","DOI":"10.1159\/000484482","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T22:01:23Z","timestamp":1517954483000},"page":"107-113","source":"Crossref","is-referenced-by-count":62,"title":["A Time-Series Study of the Effect of Air Pollution on Outpatient Visits for Acne Vulgaris in Beijing"],"prefix":"10.1159","volume":"31","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochuan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Vierk\u00f6tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Seit\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Moyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Schikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Krutmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.204"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.12.045"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.07.014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10349.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.29"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12270"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12203"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp032"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200701-036OC"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/484482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/484482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:16Z","timestamp":1745425036000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000484482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,28]]},"published-print":{"date-parts":[[2018,3,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000484482","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}