{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:17:12Z","timestamp":1783448232255,"version":"3.55.0"},"reference-count":16,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":2994,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objectives: Parathyroid hormone (PTH) is a risk marker for hypoparathyroidism (hypoPTH). This study aimed to determine the predictive values of early PTH assays carried out at the moment of skin closure (PTH SC), to establish a treatment algorithm, identifying two threshold values. We assessed the reproducibility of this approach with two different immunoassay kits (hypoPTH) after total thyroidectomy, but its practical application is not consensual. Study Design: We conducted a prospective descriptive study, including all patients who underwent a total thyroidectomy between March 2012 and November 2013. Postoperative PTH SC levels, corrected calcium on postoperative days, and occurrence of hypoPTH symptoms were collected. Results: Of 257 patients, the rate of hypoPTH was 20%. Threshold values to obtain a 100% positive predictive value to identify patients for whom hypoPTH was absolutely certain were: PTH SC &amp;lt;7 ng\/L for the Roche kit and PTH SC &amp;lt;4 ng\/L for the Beckman-Coulter kit. Threshold values to obtain a 100% negative predictive value to identify patients for whom the absence of hypoPTH was absolutely certain were: PTH SC \u226519 ng\/L for the Roche kit and PTH SC \u22659 ng\/L the Beckman-Coulter kit. Conclusions: A single serum PTH sampled at skin closure is a reliable test to predict hypoPTH after a total thyroidectomy. The use of a threshold based on a 100% negative predictive value enables patients with no risk of hypoPTH to be safely discharged within the first 24 h postoperatively without unnecessary calcium and vitamin treatment. This medication can be given promptly to patients at risk of hypoPTH to limit the occurrence of hypocalcaemia.<\/jats:p>","DOI":"10.1159\/000484689","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T17:02:00Z","timestamp":1512666120000},"page":"34-38","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":13,"title":["Parathyroid Hormone Assays following Total Thyroidectomy: Is There a Predictive Value?"],"prefix":"10.1530","volume":"7","author":[{"given":"Camille","family":"Galy-Bernadoy","sequence":"first","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1896-2649","authenticated-orcid":false,"given":"Benjamin","family":"Lallemant","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Chambon","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy\u00a0Trang","family":"Pham","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Reynaud","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Alovisetti","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Bonduelle","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u00a0Marie","family":"Guedj","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Lumbroso","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David-Paul","family":"De\u00a0Brauwere","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"2026070713074967700_ref1","doi-asserted-by":"crossref","unstructured":"Bilezikian JP, Khan A, Potts JT, et al: Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. J Bone Miner Res 2011; 26: 2317\u20132337.10.1002\/jbmr.48321812031","DOI":"10.1002\/jbmr.483"},{"key":"2026070713074967700_ref2","doi-asserted-by":"crossref","unstructured":"Reddy AC, Chand G, Sabaretnam M, et al: Prospective evaluation of intra-operative quick parathyroid hormone assay as an early predictor of post thyroidectomy hypocalcaemia. Int J Surg 2016; 34: 103\u2013108.10.1016\/j.ijsu.2016.08.01027530498","DOI":"10.1016\/j.ijsu.2016.08.010"},{"key":"2026070713074967700_ref3","doi-asserted-by":"crossref","unstructured":"Grodski S, Serpell J: Evidence for the role of perioperative PTH measurement after total thyroidectomy as a predictor of hypocalcemia. World J Surg 2008; 32: 1367\u20131373.10.1007\/s00268-008-9545-518340480","DOI":"10.1007\/s00268-008-9545-5"},{"key":"2026070713074967700_ref4","doi-asserted-by":"crossref","unstructured":"Noordzij JP, Lee SL, Bernet VJ, et al: Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies. J Am Coll Surg 2007; 205: 748\u2013754.10.1016\/j.jamcollsurg.2007.06.29818035257","DOI":"10.1016\/j.jamcollsurg.2007.06.298"},{"key":"2026070713074967700_ref5","doi-asserted-by":"crossref","unstructured":"Houlton JJ, Pechter W, Steward DL: PACU PTH facilitates safe outpatient total thyroidectomy. Otolaryngol Head Neck Surg 2011; 144: 43\u201347.10.1177\/019459981039045321493385","DOI":"10.1177\/0194599810390453"},{"key":"2026070713074967700_ref6","doi-asserted-by":"crossref","unstructured":"Jumaily JS, Noordzij P, Dukas AG, et al: Prediction of hypocalcemia after using 1- to 6-h postoperative parathyroid hormone and calcium levels: an analysed of pooled individual patient data from 3 observational studies. Head Neck 2010; 32: 427\u2013434.10.1002\/hed.2119919780054","DOI":"10.1002\/hed.21199"},{"key":"2026070713074967700_ref7","doi-asserted-by":"crossref","unstructured":"Landry CS, Grubbs EG, Hernandez M, et al: Predictable criteria for selective, rather than routine, calcium supplementation following thyroidectomy. Arch Surg 2012; 147: 338\u2013344.10.1001\/archsurg.2011.140622184134","DOI":"10.1001\/archsurg.2011.1406"},{"key":"2026070713074967700_ref8","doi-asserted-by":"crossref","unstructured":"Lang BH-H, Yih PC-L, Ng KK: A prospective evaluation of quick intraoperative parathyroid hormone assay at the time of skin closure in predicting clinically relevant hypocalcemia after thyroidectomy. World J Surg 2012; 36: 1300\u20131306.10.1007\/s00268-012-1561-922399155","DOI":"10.1007\/s00268-012-1561-9"},{"key":"2026070713074967700_ref9","doi-asserted-by":"crossref","unstructured":"Kato Y, Sato K, Sata A, et al: Hypercalcemia induced by excessive intake of calcium supplement, presenting similar findings of primary hyperparathyroidism. Endocr J 2004; 51: 557\u2013562.10.1507\/endocrj.51.55715644574","DOI":"10.1507\/endocrj.51.557"},{"key":"2026070713074967700_ref10","doi-asserted-by":"crossref","unstructured":"Pfleiderer AG, Ahmad N, Draper MR, et al: The timing of calcium measurements in helping to predict temporary and permanent hypocalcaemia in patients having completion and total thyroidectomies. Ann R Coll Surg Engl 2009; 91: 140\u2013146.10.1308\/003588409X35934919317937","DOI":"10.1308\/003588409X359349"},{"key":"2026070713074967700_ref11","doi-asserted-by":"crossref","unstructured":"Page C, Strunski V: Parathyroid risk in total thyroidectomy for bilateral, benign, multinodular goitre: report of 351 surgical cases. J Laryngol Otol 2007; 121: 237\u2013241.10.1017\/S002221510600350117054818","DOI":"10.1017\/S0022215106003501"},{"key":"2026070713074967700_ref12","doi-asserted-by":"crossref","unstructured":"de Andrade Sousa A, Salles JMP, Soares JMA, et al: Course of ionized calcium after thyroidectomy. 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Clin Lab 2012; 58: 719\u2013724.22997972"}],"container-title":["European Thyroid Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/484689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/7\/1\/34\/35787\/etj484689.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article-pdf\/7\/1\/34\/35787\/etj484689.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:45:55Z","timestamp":1783446355000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/etj\/article\/7\/1\/34\/4885\/Parathyroid-Hormone-Assays-following-Total"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000484689","relation":{},"ISSN":["2235-0802","2235-0640"],"issn-type":[{"value":"2235-0802","type":"electronic"},{"value":"2235-0640","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12,7]]}}}