{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:08:09Z","timestamp":1769126889496,"version":"3.49.0"},"reference-count":8,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>The 6-min walk test (6MWT) is a simple and inexpensive exercise test to evaluate physical functional capacity that is widely used in heart failure (HF) patients. With the 6MWT, a distance &lt;350 m is associated with increased mortality in patients with HF, and change in walking distance &gt;50 m is considered clinically relevant. To our knowledge, information on improvement in physical functional capacity with sacubitril\/valsartan, as assessed by the 6MWT, is still scant. In our daily practice, we apply this test to all patients whenever possible; therefore, we report here the findings observed in a small series of 5 patients with HF with reduced ejection fraction after a 1-month treatment with sacubitril\/valsartan at full dose. The mean distance walked on the 6MWT at baseline was 129 m (\u00b164 SD), and this value increased to 436 m (\u00b1156) after 1 month of therapy with sacubitril\/valsartan 97\/103 mg b.i.d. The mean difference from baseline was 305 m (\u00b1110). According to these preliminary findings, in clinical practice, a 1-month therapy of sacubitril\/valsartan optimized at a 97\/103-mg b.i.d. dose appears to be associated with a relevant improvement in the 6MWT.<\/jats:p>","DOI":"10.1159\/000484879","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T22:02:21Z","timestamp":1513807341000},"page":"17-20","source":"Crossref","is-referenced-by-count":16,"title":["Sacubitril\/Valsartan: Effect on Walking Test and Physical Capability"],"prefix":"10.1159","volume":"138","author":[{"given":"Luca","family":"Sgorbini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Galati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddstr.2013.11.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.04.013"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-008-0130-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01880.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-017-0330-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2016.1159957"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/484879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/484879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:20:01Z","timestamp":1745425201000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000484879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":8,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2017,12,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000484879","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}