{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:40:08Z","timestamp":1745426408049,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Ophthalmol"],"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; We report a case of refractory atopic keratoconjunctivitis (AKC) which was successfully treated with subcutaneous immunotherapy (SCIT). &lt;b&gt;&lt;i&gt;Case Report:&lt;\/i&gt;&lt;\/b&gt; A 22-year-old woman presented with severe allergic conjunctivitis for one and a half year. She failed to respond to conventional topical anti-allergic medications, topical corticosteroid, as well as topical cyclosporine A. Therefore, oral corticosteroids had to be prescribed to control the exacerbation for 1 year. Due to refractory AKC and to avoid long-term corticosteroid use, we referred her to an allergy clinic for considering the role of SCIT. Allergology investigations showed positive skin prick test and strongly elevated serum-specific IgE to &lt;i&gt;Dermatophagoides farinae&lt;\/i&gt; (Der f) and &lt;i&gt;Dermatophagoides pteronyssinus&lt;\/i&gt; (Der p). She received a conventional protocol of SCIT using Der f and Der p allergen extracts. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The patient\u2019s ocular signs and symptoms were dramatically improved 2 months after the initiation of SCIT, and oral corticosteroids could be discontinued within 3 months of the treatment. She was maintained with mast cell stabilizers and preservative-free tears without any episodes of exacerbation. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; SCIT may contribute to successful outcomes in controlling symptoms and preventing exacerbation in AKC patient. It should be considered as an alternative or even a primary treatment for patients with refractory AKC. However, the optimal SCIT protocol must be discussed with an allergist on an individual basis for the best outcome.<\/jats:p>","DOI":"10.1159\/000485174","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T22:01:34Z","timestamp":1513288894000},"page":"562-567","source":"Crossref","is-referenced-by-count":2,"title":["Successful Subcutaneous Allergen-Specific Immunotherapy in Refractory Atopic Keratoconjunctivitis: A Case Report"],"prefix":"10.1159","volume":"8","author":[{"given":"Passara","family":"Jongkhajornpong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wannada","family":"Laisuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5935\/0004-2749.20160107"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)94017-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00570.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.036"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009078.pub2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181d83875"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31822481c2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.04.2010.2919"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(88)33155-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.034"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.06.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00790.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.11.014"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112027"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410702"}],"container-title":["Case Reports in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:22:43Z","timestamp":1745425363000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000485174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,1,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000485174","archive":["Portico"],"relation":{},"ISSN":["1663-2699"],"issn-type":[{"type":"electronic","value":"1663-2699"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}