{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:20:31Z","timestamp":1778584831447,"version":"3.51.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Nephrol Dial"],"abstract":"<jats:p>Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic hormone (ADH) levels. This suggests that oxcarbazepine (or one of its metabolites) may stimulate collecting tubule V2 receptor-G protein complex independent of ADH, resulting in increased renal tubular water reabsorption. Oxcarbazepine may be useful as an alternative therapy for patients with central diabetes insipidus.<\/jats:p>","DOI":"10.1159\/000485244","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T22:01:35Z","timestamp":1517436095000},"page":"20-24","source":"Crossref","is-referenced-by-count":6,"title":["Oxcarbazepine Therapy for Complete Central Diabetes Insipidus"],"prefix":"10.1159","volume":"8","author":[{"given":"Basmah","family":"Abdallah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Hodgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Landry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"O\u2019Shea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Braden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(88)90018-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0490283"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb02930.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6125.1445"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10190"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq317"}],"container-title":["Case Reports in Nephrology and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:23:18Z","timestamp":1745425398000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000485244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":6,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,5,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000485244","archive":["Portico"],"relation":{},"ISSN":["2296-9705"],"issn-type":[{"value":"2296-9705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]}}}