{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:14:42Z","timestamp":1776449682848,"version":"3.51.2"},"reference-count":13,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Hypertension is more common in patients with rheumatoid arthritis (RA) than in the general population. It is unknown whether hypertension is due to RA-related medications or the disease itself. Therefore, we sought to investigate associations between RA-related autoantibodies, specifically antibodies to citrullinated protein antigens (ACPA) and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in first-degree relatives of RA patients, who were free of RA and RA-related medications. We hypothesized that a greater number of detectable ACPA would be associated with high SBP and DBP, independent of other risk factors in these first-degree relatives. <b><i>Methods:<\/i><\/b> We evaluated associations between ACPA and SBP and DBP in a cross-sectional study of 72 first-degree relatives (defined as parent, child, or sibling) of RA patients. Fifteen ACPA were measured using a Bio-Plex bead-based assay; each was dichotomized as positive\/negative based on pre-specified cut-points. Analysis of covariance was used to evaluate associations between ACPA positivity and SBP and DBP, adjusting for age, sex, race, body mass index (BMI), pack-years of smoking, high sensitivity C-reactive protein (hsCRP), and current use of anti-hypertensive medications. <b><i>Results:<\/i><\/b> Average age was 51 and 69% were women. Mean SBP was 119 \u00b1 18 and DBP was 74\u00a0\u00b1 9 mm Hg. Thirty-three (46%) first-degree relatives were positive for \u22651 ACPA; and were younger, had lower BMI, more pack-years of smoking, and higher hsCRP concentrations compared to ACPA negative first-degree relatives. For each additional positive ACPA, SBP was 0.98 \u00b1 0.5 mm Hg (<i>p<\/i>\u00a0= 0.05) higher, and DBP was 0.66 \u00b1 0.3 mm Hg (<i>p<\/i>\u00a0= 0.04) higher. Anti-cit-fibrinogen A (211\u2013230) positive and anti-cit-filaggrin positive first-degree relatives had 11.5 and 13.9 mm Hg higher SBP (<i>p<\/i>\u00a0= 0.02) respectively. Anti-cit-clusterin, cit-filaggrin, and cit-vimentin positive first-degree relatives had 7\u20138 mm Hg higher DBP (<i>p<\/i>\u00a0= 0.03, 0.05, 0.05 respectively), compared to being negative for these individual ACPA. Consistent with associations between ACPA, SBP, and DBP, anti-cyclic citrullinated peptides (anti-CCP2) positive first-degree relatives had 16.4\u00b1 (<i>p<\/i>\u00a0= 0.03) higher SBP and 12.1\u00b1 mm Hg (<i>p<\/i>\u00a0= 0.01) higher DBP than anti-CCP2 negative first-degree relatives. <b><i>Conclusion:<\/i><\/b> In first-degree relatives without RA, ACPA positivity is associated with higher SBP and DBP. Subclinical autoimmune processes and ACPA may play a role in the vascular changes potentially leading to hypertension prior to RA onset.<\/jats:p>","DOI":"10.1159\/000485259","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T22:01:34Z","timestamp":1513202494000},"page":"481-487","source":"Crossref","is-referenced-by-count":5,"title":["Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis"],"prefix":"10.1159","volume":"46","author":[{"given":"Jan\u00a0M.","family":"Hughes-Austin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan\u00a0W.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin\u00a0D.","family":"Deane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael\u00a0H.","family":"Weisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u00a0Kristen","family":"Demoruelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Sokolove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William\u00a0H.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.\u00a0Michael","family":"Holers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill\u00a0M.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim\u00a0H.","family":"Ix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.112"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23171"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035296"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101143"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22930"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201505"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/art.24833"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/art.38022"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-2-200801150-00005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/art.10748"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74084"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77766"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.134"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:23:24Z","timestamp":1745425404000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000485259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,1,11]]},"published-print":{"date-parts":[[2018,1,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000485259","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}