{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:33:30Z","timestamp":1791920010508,"version":"4.3.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Functional gastrointestinal disorders (FGIDs) are very common and affect populations worldwide. A majority of patients are affected by a variety of heterogenous gastrointestinal symptoms (GIS) related to the upper and lower digestive system with frequent overlap and mostly of mild to moderate degree. The herbal medicinal preparation STW\u00a05 is documented as an effective therapeutic option for treating FGID. &lt;b&gt;&lt;i&gt;Studies Conducted in Summary:&lt;\/i&gt;&lt;\/b&gt; STW\u00a05 has been in use for more than 50 years in clinical practice and proven to be effective and safe in the management of FGID. The high efficacy of STW\u00a05 on symptoms clustered in functional dyspepsia (FD) and irritable bowel syndrome (IBS) as well as on individual abdominal symptoms is demonstrated in 5 controlled, randomized double-blind studies in FD and in one trial conducted in patients with IBS. In addition the beneficial therapeutic effect of STW\u00a05 on FGD as well as safety issues have been reported in a series of non interventional studies conducted in several thousands of adult patients and including 980 children. An additional study has been performed addressing the question as to how quickly the therapeutic effect is obtained after STW\u00a05 administration. &lt;b&gt;&lt;i&gt;Key Messages from These Studies:&lt;\/i&gt;&lt;\/b&gt; STW\u00a05 is an effective phyto-medication for treating patients with FD and IBS. STW\u00a05 acts beneficially on abdominal symptom clusters as well as on individual GIS in adults and children. The time to onset of action is rapid, well tolerated and safe. The repetitive use of STW\u00a05 is an appropriate option in clinical practice for patients with FGID.<\/jats:p>","DOI":"10.1159\/000485410","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T17:01:37Z","timestamp":1518109297000},"page":"25-29","source":"Crossref","is-referenced-by-count":49,"title":["STW\u00a05 (Iberogast) Therapy in Gastrointestinal Functional Disorders"],"prefix":"10.1159","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8439-9036","authenticated-orcid":false,"given":"Peter","family":"Malfertheiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i4.564"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32130"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.01183.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2008.01249.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01142.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(11)60415-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.01859.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-017-0578-y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-012-0169-x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18536"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:24:22Z","timestamp":1745411062000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000485410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":11,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2018,3,12]]},"published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000485410","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}