{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:32:33Z","timestamp":1763037153108,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> STW\u00a05 is a complex herbal combination preparation composed of 9 different herbal extracts. As an herbal medicinal product, this preparation is indicated for treating functional dyspepsia (FD) and irritable bowel syndrome (IBS). Its efficacy and practical applicability was demonstrated in several clinical studies. <b><i>Summary:<\/i><\/b> Each herbal constituent of STW\u00a05 has distinct effects on the gastrointestinal tract, and each shows activity through different mechanisms of action: among others, the single extracts have effects on nerves, smooth muscles, epithelial, and inflammatory cells. For example, they have relaxing or tonicizing effects on gastrointestinal muscles, and they counteract inflammation through different physiological systems, contributing to the clinical efficacy through modulation of multiple therapeutic targets. <b><i>Key Messages:<\/i><\/b> STW\u00a05 is a role model for the concept of multi-targeting in therapy. Especially in complex syndromes such as FD and IBS, simultaneous multi-targeting of different functional causes seems to be a more promising approach than the classical paradigm of one disease \u2013 one receptor \u2013 one effect.<\/jats:p>","DOI":"10.1159\/000485456","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T22:01:37Z","timestamp":1518127297000},"page":"18-24","source":"Crossref","is-referenced-by-count":21,"title":["Mechanism of Action of STW\u00a05 in Functional Dyspepsia and IBS: The Origin of Multi-Target"],"prefix":"10.1159","volume":"35","author":[{"given":"Hans-Dieter","family":"Allescher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba","family":"Abdel-Aziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016\/j.phymed.2006.05.001"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1111\/j.1365-2982.2004.00548.x"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016\/j.phymed.2006.03.020"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1111\/j.1572-0241.2007.01142.x"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1254\/jphs.09355FP"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016\/j.phymed.2006.08.004"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016\/j.phymed.2006.03.013"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1007\/s00384-012-1473-z"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016\/S0016-5085(16)33066-9"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1016\/j.phymed.2006.03.015"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1111\/j.1365-2982.2004.00576.x"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016\/j.phymed.2006.03.014"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1016\/j.phymed.2006.03.012"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.2119\/molmed.2015.00098"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1055\/s-0031-1300078"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016\/j.phymed.2006.03.019"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1016\/j.phymed.2008.10.011"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1007\/s00210-011-0714-y"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1016\/S0016-5085(16)33042-6"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.4161\/cbt.8.10.8146"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.3109\/09553002.2014.954059"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1016\/j.phymed.2014.04.030"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1016\/j.phymed.2013.02.011"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.3389\/fphar.2016.00393"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1055\/s-0043-116852"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1016\/j.phymed.2006.03.018"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.1111\/j.1365-2982.2008.01242.x"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1016\/j.phymed.2015.08.008"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:24:50Z","timestamp":1745425490000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000485456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":28,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2018,3,12]]},"published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000485456","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"type":"print","value":"0257-2753"},{"type":"electronic","value":"1421-9875"}],"subject":[],"published":{"date-parts":[[2017]]}}}