{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:24:05Z","timestamp":1787318645225,"version":"build-2736575974"},"reference-count":41,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Cisplatin is a chemotherapeutic agent. The use of remote ischemic preconditioning (RIPC) was proposed after the observation that ischemic preconditioning of a cardiac vascular area could protect another completely distinctly. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This is an experimental study. Male Wistar rats were anesthetized, and they underwent a hearing evaluation via measurement of the brainstem auditory evoked potential (BSAEP). Then, cisplatin was administered intraperitoneally (IP) at a dose of 8 mg\/kg\/day for 4 consecutive days to group 1, whereas saline solution was administered IP to group 2. In groups 3 and 4, ischemia of the right hind paw was performed for 10 min, followed by reperfusion for 30 min, after which cisplatin or saline was administered IP to group 3 or group 4, respectively. Afterwards, all animals were evaluated via the BSAEP. The right cochlea was dissected for immunohistochemistry. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; RIPC lowered the increase in BSAEP of the animals treated with cisplatin (&lt;i&gt;p&lt;\/i&gt; = 0.0146). Weight loss decreased in the animals subjected to RIPC (&lt;i&gt;p&lt;\/i&gt; &lt; 0.005). In group 3, RIPC reversed immunostaining for tumor necrosis factor-\u03b1 and inducible nitric oxide synthase in the stria vascularis injured by cisplatin (&lt;i&gt;p&lt;\/i&gt; &lt; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; RIPC protects against systemic toxicity and ototoxicity induced by cisplatin in rats.<\/jats:p>","DOI":"10.1159\/000485514","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T17:01:23Z","timestamp":1516122083000},"page":"336-346","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Remote Ischemic Preconditioning on Systemic Toxicity and Ototoxicity Induced by Cisplatin in Rats: Role of TNF-\u03b1 and Nitric Oxide"],"prefix":"10.1159","volume":"79","author":[{"given":"Marcos Jullian Barreto","family":"Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avner Marcos 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