{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:05:19Z","timestamp":1788404719572,"version":"build-2803163510"},"reference-count":16,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; To date, there is no imaging technique to assess tubular function &lt;i&gt;in vivo&lt;\/i&gt;. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tubule-specific pharmacological maneuver. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Cross sectional study with 28 participants including 9 subjects with ATN-induced acute kidney injury (AKI), 9 healthy controls, and 10 subjects with nephron sparing tumor resection (NSS) with clamping of the renal artery serving as a model of ischemia\/reperfusion (I\/R)-induced subclinical ATN (median clamping time 15 min, no significant decrease of eGFR, p=0.14). BOLD MRI was performed before and 5, 7, and 10 min after intravenous administration of 40 mg furosemide. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Urinary neutrophil gelatinase-associated lipocalin was significantly higher in ATN-induced AKI and NSS subjects than in healthy controls (p=0.03 and p=0.01, respectively). Before administration of furosemide, absolute medullary R2*, cortical R2*, and medullary\/cortical R2* ratio did not significantly differ between ATN-induced AKI vs. healthy controls and between NSS-I\/R vs. contralateral healthy kidneys (p&amp;#x3e;0.05 each). Furosemide led to a significant decrease in the medullary and cortical R2* of healthy subjects and NSS contralateral kidneys (p&amp;#x3c;0.05 each), whereas there was no significant change of R2* in ATN-induced AKI and the NSS-I\/R kidneys (p&amp;#x3e;0.05 each). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; BOLD-MRI is able to detect even mild tubular injury but necessitates a tubule-specific pharmacological maneuver, e.g. blocking the Na&lt;sup&gt;+&lt;\/sup&gt;-K&lt;sup&gt;+&lt;\/sup&gt;-2Cl&lt;sup&gt;-&lt;\/sup&gt; transporter by furosemide.<\/jats:p>","DOI":"10.1159\/000485600","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T22:04:22Z","timestamp":1512165862000},"page":"1078-1089","source":"Crossref","is-referenced-by-count":14,"title":["Detection of Acute Tubular Necrosis Using Blood Oxygenation Level-Dependent (BOLD) 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