{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:37:39Z","timestamp":1768592259319,"version":"3.49.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Resting metabolic rate (RMR) used to prognosticate and measure the amount of energy required. Vitamin D is known as a new predictor of RMR. The aim of this study is to investigate the relationship between vitamin D effects on RMR in connection with the vitamin D receptor (<i>VDR<\/i>) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (<i>PGC-1\u03b1<\/i>) gene expression. <b><i>Methods:<\/i><\/b> We enrolled 298 overweight and obese adults in this cross-sectional study. Body mass index (BMI), fat mass, fat-free mass, insulin level, visceral fat, and vitamin D status were assessed. RMR was measured by means of indirect calorimetry. The real-time polymerase chain reaction using specific primer pairs for <i>VDR<\/i> and <i>PGC-1\u03b1<\/i> was performed. <b><i>Results:<\/i><\/b> There were significant differences in terms of fat free mass, fat percentage, insulin levels, RMR\/kg body weight, and RMR\/BMI, <i>VDR<\/i>, and <i>PGC-1\u03b1<\/i> among participants were categorized based on the vitamin D status. But after using general linear model for adjusting, all significant results missed their effectiveness except RMR\/kg body weight and <i>VDR<\/i>. Linear regression analysis used to show the mediatory role of <i>VDR<\/i> and <i>PGC-1\u03b1<\/i> on the RMR\/kg body weight and vitamin D status relationship. Our results showed that <i>VDR<\/i> had a mediatory effect on the relationship between RMR\/kg body weight and vitamin D status (\u03b2\u00a0= 0.38, 95% CI \u20130.48 to 1.60; \u03b2\u00a0= \u20131.24, 95% CI \u20135.36 to 1.70). However, <i>PGC-1\u03b1<\/i> did not affect the relationship between RMR\/kg body weight and vitamin D status (\u03b2\u00a0= 0.50, 95% CI\u00a0= \u20130.02 to 3.42; \u03b2\u00a0= 0.59, 95% CI 0.14\u20133.90). <b><i>Conclusion:<\/i><\/b> Our study showed the mediatory effect of <i>VDR<\/i> gene expression in the association of 25(OH)<sub>2<\/sub>D plasma levels and resting metabolic rate among obese individuals.<\/jats:p>","DOI":"10.1159\/000485662","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T22:01:34Z","timestamp":1513720894000},"page":"43-49","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D Status and Resting Metabolic Rate May Modify through Expression of Vitamin D Receptor and Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene in Overweight and Obese Adults"],"prefix":"10.1159","volume":"72","author":[{"given":"Seyedeh\u00a0Forough","family":"Sajjadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadijeh","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Khorrami-Nezhad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhila","family":"Maghbooli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed\u00a0Ali","family":"Keshavarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13522"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000382080"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-382"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2764"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-1021-z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2011.03.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90763.2008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.106"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512003285"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0003319714528569"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2014.06.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.06.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.257568"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.012708"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2005.04184.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1011"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-3914-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159\/000337352"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-0948-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2014.133"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12239"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.226"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.200"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1298"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.226"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-182139"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3592"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611623104"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13175"}],"container-title":["Annals 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