{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:37:59Z","timestamp":1790534279078,"version":"4.1.0"},"reference-count":40,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Hemorrhagic cystitis (HC) is a serious complication after hematopoietic stem cell transplantation (HSCT). Stromal cells have been tested as therapy for HC. Decidua stromal cells (DSCs) protect the fetus from the mother's immune system. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Eleven patients with HC of grades 3-4 were treated with DSCs after HSCT. The median age was 33 years (range 8-50), and the median dose of DSCs was 1.5 \u00d7 10&lt;sup&gt;6&lt;\/sup&gt;\/kg (range 0.7-2.5). The patients were given 1 dose (1-4). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In 5 patients, HC disappeared within 5 days after DSC infusion. Patients who received DSCs within 3 days after the start of HC had a duration of HC of 5 days and a shorter duration of pain than patients who were given DSCs later (&lt;i&gt;p&lt;\/i&gt; = 0.02). Three patients received DSCs prepared in albumin instead of AB-plasma and tended to have a shorter duration of pain (&lt;i&gt;p&lt;\/i&gt; = 0.07). There was no infusion toxicity. Adverse events were those often seen after HSCT. Nine of the 11 patients (82%) were alive 1 year after HSCT. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Based on this pilot study, we started a randomized, placebo-controlled double-blind study using 2 doses of 1 \u00d7 10&lt;sup&gt;6&lt;\/sup&gt; DSCs\/kg suspended in albumin for treatment of early HC.<\/jats:p>","DOI":"10.1159\/000485735","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T22:01:30Z","timestamp":1517954490000},"page":"106-114","source":"Crossref","is-referenced-by-count":30,"title":["Placenta-Derived Decidua Stromal Cells for Hemorrhagic Cystitis after Stem Cell 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