{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:06:19Z","timestamp":1776171979509,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Objective:<\/i><\/b> The current study was carried out to compare pulmonary function tests (PFTs) in pediatric Kuwaiti sickle cell disease (SCD) patients to age-matched normal controls and to investigate the association of PFTs with selected clinical and laboratory parameters. <b><i>Subjects and<\/i><\/b><b><i>Methods:<\/i><\/b> There were 38 patients with SCD and 36 controls in the study. The patients were recruited from the Pediatric Hematology Clinics of Mubarak Al-Kabeer and Al-Amiri Hospitals, Kuwait, and were studied in steady state. The controls were healthy, non-sickle cell siblings of the patients. Forced expiratory volume in 1 s (FEV<sub>1<\/sub>), forced vital capacity (FVC), total lung capacity, and other PFT parameters were obtained using a constant-volume, variable-pressure, body plethysmograph. Hemoglobin, fetal hemoglobin, serum bilirubin, and lactate dehydrogenase were determined using standard methods. <b><i>Results:<\/i><\/b> The mean ages of the patients and controls were 10.5 \u00b1 3.2 and 10.5 \u00b1 3.5 years, respectively. The FEV<sub>1<\/sub>% predicted of 84.1 \u00b1 15.4% among the patients was significantly lower than the 92.1 \u00b1 11.8% in the controls (<i>p<\/i> = 0.003). The FVC% predicted was also significantly lower (<i>p<\/i> = 0.022) in the patients than in the controls, although the values were generally within the normal range. There was no association of FEV<sub>1<\/sub> with pain phenotype, acute chest syndrome (ACS), or blood transfusions. Also, there was no significant correlation with reticulocytes, bilirubin, or lactate dehydrogenase. <b><i>Conclusions:<\/i><\/b> In this study, changes in PFT, especially FEV<sub>1<\/sub>, developed early in the SCD patients. There was no demonstrable association with frequent vaso-occlusive crisis, ACS, and other variables. Hence, there is a need for follow-up studies with serial PFTs to identify vulnerable patients, who might need intervention to prevent early mortality.<\/jats:p>","DOI":"10.1159\/000485801","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T22:02:21Z","timestamp":1511906541000},"page":"49-54","source":"Crossref","is-referenced-by-count":10,"title":["Correlates of Pulmonary Function in Children with Sickle Cell Disease and Elevated Fetal Hemoglobin"],"prefix":"10.1159","volume":"27","author":[{"given":"Adekunle D.","family":"Adekile","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa Farag","family":"Azab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Owayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mousa","family":"Khadadah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-644435"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24598"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.783570"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.059"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035477"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.07.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1109130#SA2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-011072"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.029165"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-3-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21475"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.01.008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000203753"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2004.00216.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000312716"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000129607"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201606-452ED"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-015-0014-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000239"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12895"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2013.10.002"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000102151"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12650"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-016-2065-7"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:36Z","timestamp":1745425656000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000485801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,4,19]]},"published-print":{"date-parts":[[2018,4,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000485801","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]}}}