{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:29:34Z","timestamp":1779193774448,"version":"3.51.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncol Res Treat"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Pelvic lymphadenectomy, which is the routine surgical treatment for early-stage cervical cancer, causes serious morbidity. The goal of the current retrospective study was to identify predictive factors of lymph node metastasis (LNM) in patients with early-stage cervical cancer. <b><i>Patients and Methods:<\/i><\/b> The study included 496 patients diagnosed with stages IA2-IB1cervical cancer who underwent a radical hysterectomy with pelvic lymphadenectomy. The predictive factors of LNM were evaluated. <b><i>Results:<\/i><\/b> The incidence of LNM in this study was 4.6%. LNM was more common in patients with deep stromal invasion (DSI), tumor size > 2 cm, lymph vascular invasion and parametrial involvement (PI). Multivariate analysis showed DSI (p = 0.010) and PI (p = 0.005) were independently associated with LNM. The median follow-up time was 56.9 months. The patients with LNM had poorer 5-year overall survival (77.8%; 95% confidence interval (CI) 44.2-92.6) than the patients without LNM (98.2%; 95% CI 95.6-99.2; p = 0.002) and also poorer 5-year recurrence-free survival (65.5%; 95% CI 38.6-82.8) than the patients without LNM (90.2%; 95% CI 86.5-92.9; p < 0.001). <b><i>Conclusion:<\/i><\/b> The predictive factors of pelvic lymph node metastasis in stage IA2-IB1 cervical cancer patients were DSI and PI. LNM was associated with poorer oncological outcomes.<\/jats:p>","DOI":"10.1159\/000485840","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T22:01:19Z","timestamp":1521669679000},"page":"194-198","source":"Crossref","is-referenced-by-count":43,"title":["Predictive Factors of Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer"],"prefix":"10.1159","volume":"41","author":[{"given":"Kulisara","family":"Nanthamongkolkul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-6824","authenticated-orcid":false,"given":"Jitti","family":"Hanprasertpong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.08.019"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3067-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.12.014"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.10.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2927-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000447335"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.7150\/jca.10968"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25408"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.09.037"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.09.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30509"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-016-4279-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2017.28.e42"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.03.037"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000464408"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000163"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.09.042"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2267::AID-CNCR10>3.3.CO;2-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.09.025"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000878"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.113128"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550130070040"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000169"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.02.010"}],"container-title":["Oncology Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:48Z","timestamp":1745425668000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000485840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,9]]},"published-print":{"date-parts":[[2017,4,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000485840","archive":["Portico"],"relation":{},"ISSN":["2296-5270","2296-5262"],"issn-type":[{"value":"2296-5270","type":"print"},{"value":"2296-5262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}