{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:56:38Z","timestamp":1777640198406,"version":"3.51.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Evaluate the prevalence of Fabry disease in men and women with kidney disease; and observe the presence and importance of the main signs and symptoms in patients with kidney disease. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A cross-sectional analysis of secondary data from a multicenter project of Clinical and Epidemiological Analysis of Fabry Disease in 854 Dialysis Centers. A total of 36,442 patients underwent the questionnaire and algorithm; of them, 28,284 were discarded for not presenting signs and symptoms of Fabry disease, while the other 8,087 submitted to blood collection and analysis. All participants signed a Free and Informed Consent Form and a questionnaire was applied. The questionnaire data were analyzed using a computerized algorithm. This program\/algorithm analyzes and separates patients into: discarded, patients unlikely to have Fabry disease; suspect, patients who submitted to blood collection. The blood of suspect patients was collected on filter paper for enzyme measurement and genetic testing. A descriptive data analysis was performed and the likelihood ratio was determined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The general prevalence was 0.19% and after use of algorithm was 0.87%. Although more men were screened (59.3%), the prevalence was higher in women (65.1%). The most prevalent signs and symptoms were: heart disease (60.6%), decreased or lack of sweating (42.3%), heat and cold intolerance (28.2%), and pain crises spreading throughout the body (26.8%). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The prevalence was higher in women, and the most prevalent symptom was heart diseases.<\/jats:p>","DOI":"10.1159\/000485929","type":"journal-article","created":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T22:01:53Z","timestamp":1513375313000},"page":"1258-1265","source":"Crossref","is-referenced-by-count":10,"title":["Screening for Fabry Disease in Kidney Disease: a Cross-Sectional Study in Males and Females"],"prefix":"10.1159","volume":"42","author":[{"given":"Luciana\u00a0Senra\u00a0de\u00a0Souza","family":"Sodr\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e1lia\u00a0Maria\u00a0Nunes\u00a0Henriques","family":"Huaira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus\u00a0Gomes","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando\u00a0Ant\u00f4nio\u00a0Basile","family":"Colugnati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo\u00a0Paula","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia\u00a0Maria\u00a0da\u00a0Silva","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.12.1526"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.01.051"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61589-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318183f132"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.09.013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2004.04.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2008.00791.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2012.01092.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/08860220802353777"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-19"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5414\/CN108053"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.05.050"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-015-1146-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12408"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5935\/0101-2800.20160009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142785"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006005000138"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000464312"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000452605"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-81232010000900019"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/485929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:28:56Z","timestamp":1745425736000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000485929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,1,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000485929","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}