{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T20:52:32Z","timestamp":1771966352777,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Background:<\/i><\/b> Despite improvements in perinatal care, bronchopulmonary dysplasia (BPD) in extremely premature infants has not decreased. Postnatal surfactant therapy provides symptomatic relief from respiratory distress syndrome, but does not translate into a reduction in BPD. Therefore, the search for effective interventions to prevent BPD continues. <b><i>Objectives:<\/i><\/b> Since PPAR-\u03b3 agonists have been demonstrated to promote neonatal lung maturation and injury repair, we hypothesized that a formulation of a PPAR-\u03b3 agonist, pioglitazone (PGZ) and a synthetic lung surfactant (a surfactant protein B peptide mimic, B-YL) combined would stimulate lung maturation and block hyperoxia-induced neonatal lung injury more effectively than either modality alone. <b><i>Methods:<\/i><\/b> One-day-old Sprague-Dawley rat pups were administered PGZ + B-YL via nebulization every 24 h for up to 72 h. The pups were exposed to either 21 or 95% O<sub>2<\/sub>, and then sacrificed. Their lungs were examined for markers of lung maturation (levels of PPAR-\u03b3, SP-C and choline-phosphate cytidylyltransferase [CCT-\u03b1] and [<sup>3<\/sup>H]triolein uptake) and injury repair (bronchoalveolar lavage cell count and protein content, and levels of LEF-1, fibronectin, ALK5, and \u03b2-catenin) by Western blot analysis. <b><i>Results:<\/i><\/b> Markers of alveolar epithelial\/mesenchymal maturation (PPAR-\u03b3, SP-C, CCT-\u03b1, and triolein uptake) increased significantly in the PGZ + B-YL group, more than with either drug alone. Similarly, markers of hyperoxia-induced lung injury were blocked effectively with PGZ + B-YL treatment. <b><i>Conclusions:<\/i><\/b> Nebulized PPAR-\u03b3 agonist PGZ with a synthetic lung surfactant accelerates lung maturation and prevents neonatal hyperoxia-induced lung injury more than either modality alone, with the potential to provide more effective prevention of BPD.<\/jats:p>","DOI":"10.1159\/000486188","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T22:01:35Z","timestamp":1518213695000},"page":"296-304","source":"Crossref","is-referenced-by-count":22,"title":["A Combination of the Aerosolized PPAR-\u03b3 Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats"],"prefix":"10.1159","volume":"113","author":[{"given":"Reiko","family":"Sakurai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humphrey","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan\u00a0J.","family":"Waring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans\u00a0J.","family":"Walther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virender\u00a0K.","family":"Rehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.19"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2013.03.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00268.2015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181938c40"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90392.2008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00082.2013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008672"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.403"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000156244.84422.55"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2009.0758"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00071.2006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001039"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.07.013"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000486188"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31806772a1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000238326.42590.03"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/pdp.22.3.189.207"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5793"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9007-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/342924"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000451076"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00076.2011"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:31:06Z","timestamp":1745425866000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,5,31]]},"published-print":{"date-parts":[[2018,5,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000486188","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}