{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:57:09Z","timestamp":1759694229854,"version":"3.40.5"},"reference-count":20,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Addict Res"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Atrial natriuretic peptide (ANP) is well known in psychiatric disorders to modulate hypothalamic-pituitary-adrenal axis activity. Disturbances of ANP have been described in early abstinent alcohol-dependent patients. This is the first longitudinal investigation on cytosine-phosphatidyl-guanine (CpG)-island promoter methylation of the &lt;i&gt;ANP&lt;\/i&gt; gene in the blood of tobacco-dependent patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In a longitudinal approach, we investigated whether changes in ANP serum levels correlated to CpG methylation of the respective gene promoters on days 1, 7, and 14 of tobacco withdrawal. &lt;b&gt;&lt;i&gt;Results&lt;\/i&gt;&lt;\/b&gt; &lt;b&gt;&lt;i&gt;and Conclusion:&lt;\/i&gt;&lt;\/b&gt; Compared to non-smokers, promoter-related deoxyribonucleic acid methylation of the ANP promoter was significantly elevated on days 7 and 14 of withdrawal in tobacco-dependent patients. Baseline methylation status of the ANP promoter was not significantly different from controls, arguing for an impaired regulation during withdrawal.<\/jats:p>","DOI":"10.1159\/000486279","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T22:01:29Z","timestamp":1516140089000},"page":"306-311","source":"Crossref","is-referenced-by-count":5,"title":["Smoking and Promoter-Specific Deoxyribonucleic Acid Methylation of the Atrial Natriuretic Peptide Gene: Methylation of Smokers and Non-Smokers Differs Significantly during Withdrawal"],"prefix":"10.1159","volume":"23","author":[{"given":"Alexander","family":"Glahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-9843","authenticated-orcid":false,"given":"Mathias","family":"Rhein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Frieling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-5159","authenticated-orcid":false,"given":"Rilana","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"El\u00a0Aissami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bleich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hillemacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Muschler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011519"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/tc.2006.016030"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.11.049"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.07.060"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00479.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/ahg.12153"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agt160"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.4.371"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1255-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000357473"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2015.01.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01732.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.02.019"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.108"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063812"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307480"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds488"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2016-0001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001506"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4161\/15592294.2014.969637"}],"container-title":["European Addiction Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:16Z","timestamp":1745425936000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,2,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000486279","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5788839","asserted-by":"subject"}]},"ISSN":["1022-6877","1421-9891"],"issn-type":[{"type":"print","value":"1022-6877"},{"type":"electronic","value":"1421-9891"}],"subject":[],"published":{"date-parts":[[2017]]}}}