{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:37:12Z","timestamp":1776865032708,"version":"3.51.2"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Extra"],"abstract":"<b><i>Purpose:<\/i><\/b> Human infection with Dobrava-Belgrade virus (DOBV) in Northern Germany causes a mild form of hantavirus disease predominantly characterized by acute kidney injury due to interstitial nephritis. We evaluated the largest number of DOBV-infected patients so far regarding clinical course, proteinuria, and prognostic markers. <b><i>Patients and Methods:<\/i><\/b> Patients with DOBV-associated hantavirus disease admitted to the Renal Division of the University of L\u00fcbeck (Germany) between 1997 and 2012 were included in this study. Symptoms, clinical course, laboratory parameters, and urinary protein analysis were investigated at admission (baseline, t<sub>0<\/sub>), 3\u20135 days (t<sub>3\u20135<\/sub>), 10\u201317 days (t<sub>10\u201317<\/sub>), and after 1 year of follow-up (t<sub>365<\/sub>). <b><i>Results:<\/i><\/b> Of the 34 patients (male\/female ratio: 23\/11; age: 41 \u00b1 14 years) included in the study, 4 underwent hemodialysis (HD). Glomerular filtration rate was 17 \u00b1 14 mL\/min at t<sub>0<\/sub> and increased to 27 \u00b1 26 mL\/min (t<sub>3\u20135<\/sub>), 57 \u00b1 20 mL\/min (t<sub>10\u201317<\/sub>), and 84 \u00b1 16 mL\/min (t<sub>365<\/sub>). Albuminuria and tubular proteinuria (\u03b1<sub>1<\/sub>- and \u03b2<sub>2<\/sub>-microglobulin) decreased during follow-up; the urinary \u03b1<sub>1<\/sub>-microglobulin concentration in patients who required HD was significantly higher than that in patients not requiring HD (t<sub>0<\/sub>: 186 \u00b1 51 vs. 45 \u00b1 26 mg\/g creatinine; t<sub>3\u20135<\/sub>: 87 \u00b1 14 vs. 32 \u00b1 16 mg\/g creatinine; t<sub>10\u201317<\/sub>: 63 \u00b1 18 vs. 28 \u00b1 12 mg\/g creatinine; <i>p<\/i> &#x3c; 0.001). <b><i>Conclusions:<\/i><\/b> DOBV infection of inpatients in Northern Germany is associated with severe kidney injury that recovers within a few weeks and normalizes within 1 year. Tubular proteinuria is associated with the severity of kidney injury and the necessity of renal replacement therapy in these DOBV-infected patients.<\/jats:p>","DOI":"10.1159\/000486322","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T22:01:31Z","timestamp":1518213691000},"page":"1-10","source":"Crossref","is-referenced-by-count":16,"title":["Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection"],"prefix":"10.1159","volume":"8","author":[{"given":"Markus","family":"Meier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram\u00a0J.","family":"Jabs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlev\u00a0H.","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Lehnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Nitschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2013.0461"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.08.033"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3201\/eid0302.970202"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1722"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-012-1514-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01225-09"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12543"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2016.1274421"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000213899"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(90)90246-R"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-4-829"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2756-2763.2005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3201\/eid1404.071310"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2007.026"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.02.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh485"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.118"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.04.030"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu319"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000459634"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2012.03994.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0699-9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3201\/eid2101.140861"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1180-9"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-132"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12257"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3201\/eid1008.031069"}],"container-title":["Nephron Extra"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:51Z","timestamp":1745425971000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,5,9]]}},"URL":"https:\/\/doi.org\/10.1159\/000486322","archive":["Portico"],"relation":{},"ISSN":["1664-5529"],"issn-type":[{"value":"1664-5529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,9]]}}}