{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:36:57Z","timestamp":1790800617950,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;Background\/Aims:&lt;\/b&gt; Ultrafiltration rate (UFR) appears to be associated with mortality in prevalent hemodialysis (HD) patients. However, the association of UFR with mortality in incident HD patients remains unknown. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We examined a US cohort of 110,880 patients who initiated HD from 2007 to 2011. Baseline UFR was divided into 5 groups (&amp;#x3c;4, 4 to &amp;#x3c;6, 6 to &amp;#x3c;8, 8 to &amp;#x3c;10, and \u226510 mL\/h\/kg body weight [BW]). We examined predictors of higher baseline UFR using logistic regression and the association of baseline UFR and all-cause and cardiovascular (CV) mortality using Cox proportional hazard models with adjustments for demographics, comorbidities, and markers of malnutrition-inflammation-cachexia syndrome. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Patients were 63 \u00b1 15 years, with 43% women, 32% African Americans, and had a mean baseline UFR of 7.5 \u00b1 3.1 mL\/h\/kg BW. In the fully adjusted logistic regression models, factors associated with higher UFR (\u22657.5 mL\/h\/kg BW) included Hispanic ethnicity, diabetes, and higher dietary protein intake. There was a linear association between UFR and all-cause and CV mortality, where UFR \u226510 mL\/h\/kg BW (reference UFR 6\u2013&amp;#x3c;8 mL\/h\/kg BW) conferred the highest risk in both unadjusted (HR 1.15 [95% CI 1.10\u20131.19]) and  adjusted models (HR 1.23 [95% CI 1.16\u20131.31]). The linear association with all-cause mortality remained consistent across strata of age, urine volume, and treatment time. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Higher UFR is independently associated with higher all-cause and CV mortality in incident HD patients. Clinical trials are warranted to examine the effects of lowering UFR on outcomes.<\/jats:p>","DOI":"10.1159\/000486323","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T22:01:45Z","timestamp":1516312905000},"page":"13-22","source":"Crossref","is-referenced-by-count":37,"title":["Association of Ultrafiltration Rate with Mortality in Incident Hemodialysis Patients"],"prefix":"10.1159","volume":"139","author":[{"given":"Tae\u00a0Woo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u00a0Ik","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u00a0Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason\u00a0A.","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Soohoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa\u00a0A.","family":"Ravel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8204-911X","authenticated-orcid":false,"given":"Csaba\u00a0P.","family":"Kovesdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-0725","authenticated-orcid":false,"given":"Kamyar","family":"Kalantar-Zadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elani","family":"Streja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000123691.46138.E2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000046262"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(98)70052-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000065228"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2006.00199_1.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027342"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.5.884"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.4.919"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm466"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.383"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv097"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.09314.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000349931"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000362743"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.807362"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg450"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03900808"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014020222"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.08.007"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09460912"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000096403"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.06.020"}],"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/486323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:52Z","timestamp":1745425972000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000486323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,4,26]]},"published-print":{"date-parts":[[2018,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000486323","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5798043","asserted-by":"subject"}]},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}